Galectin-3 secreted by human umbilical cord blood-derived mesenchymal stem cells reduces amyloid-beta42 neurotoxicity in vitro

FEBS Letters
Ju-Yeon KimJong Wook Chang

Abstract

In this study, we found that expression and secretion of galectin-3 (GAL-3) were upregulated by amyloid-beta42 (Abeta42) exposure in human umbilical cord blood-derived mesenchymal stem cell (hUCB-MSC) without cell death. Abeta42-exposed rat primary cortical neuronal cells co-treated with recombinant GAL-3 were protected from neuronal death in a dose-dependent manner. hUCB-MSCs were cocultured with Abeta42-exposed rat primary neuronal cells or the neuroblastoma cell line, SH-SY5Y in a Transwell chamber. Coculture of hUCB-MSCs reduced cell death of Abeta42-exposed neurons and SH-SY5Y cells. This neuroprotective effect of hUCB-MSCs was reduced significantly by GAL-3 siRNA. These data suggested that hUCB-MSC-derived GAL-3 is a survival factor against Abeta42 neurotoxicity.

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Citations

Jan 8, 2013·World Journal of Stem Cells·Ju-Yeon KimJong Wook Chang
Jul 20, 2016·Molecular Therapy : the Journal of the American Society of Gene Therapy·SooJin KwonJong Wook Chang
Jul 26, 2015·Alzheimer's & Dementia : Translational Research & Clinical Interventions·Hee Jin KimDuk L Na
May 28, 2019·Cell Death and Differentiation·Chih-Chieh TaoEminy H Y Lee
May 24, 2019·Molecular Neurobiology·Evelyn PardoAlfonso González

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