Galectin-9: An anticancer molecule for gallbladder carcinoma

International Journal of Oncology
Tomoko TadokoroTsutomu Masaki

Abstract

Gallbladder cancer (GBC) is the most common and aggressive type of biliary tract cancer. There are various histological types of GBC, and the vast majority of GBC cases are adenocarcinomas. Squamous and adenosquamous carcinomas are rare GBC subtypes that are traditionally considered to be more aggressive and to be associated with a poorer prognosis than adenocarcinoma. Galectin-9 (Gal-9), a tandem-repeat-type galectin, has been reported to induce apoptosis-mediated elimination of various cancers, including hepatocellular carcinoma, cholangiocarcinoma, and hematologic malignancies. Therefore, we investigated the antitumor effects of Gal-9 on GBC in vitro and in vivo. In our in vitro experiments, Gal-9 suppressed cell proliferation in various GBC cell lines but not in the OCUG-1 cell line, which represents a poorly differentiated type of adenosquamous carcinoma. Gal-9 induced the apoptosis of Gal-9-sensitive GBC cells by increasing the levels of caspase-cleaved keratin 18 and phosphorylated p53. However, Gal-9 did not affect the expression of various cell cycle-related proteins. In addition, Gal-9 suppressed tumor growth by implanted human GBC cells in a xenograft model. Furthermore, Gal-9 induced the phosphorylation of the Ephri...Continue Reading

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Citations

Jan 4, 2017·International Journal of Molecular Sciences·Koji FujitaTsutomu Masaki
May 10, 2017·International Journal of Molecular Sciences·Fabio Dall'Olio, Marco Trinchera
Feb 2, 2018·International Journal of Molecular Sciences·Feng-Cheng ChouHuey-Kang Sytwu
Dec 30, 2016·Allergy·E Jensen-JarolimS N Karagiannis
Jun 29, 2017·International Journal of Oncology·Tomoko TadokoroTsutomu Masaki
Sep 2, 2016·Journal of Biosciences·Sebastian John, Rashmi Mishra
Nov 10, 2017·Cellular and Molecular Life Sciences : CMLS·Cherylane Dubé-Delarosbil, Yves St-Pierre
May 31, 2019·International Journal of Molecular Sciences·Taiga ChiyoTsutomu Masaki
Oct 22, 2020·Antibodies·Jitesh ChauhanHeather J Bax
Oct 22, 2020·Journal for Immunotherapy of Cancer·Peixin ChenCaicun Zhou
Apr 18, 2021·Cytokine & Growth Factor Reviews·Natalia PorębskaŁukasz Opaliński

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