GALGO: an R package for multivariate variable selection using genetic algorithms

Bioinformatics
Victor Trevino, Francesco Falciani

Abstract

The development of statistical models linking the molecular state of a cell to its physiology is one of the most important tasks in the analysis of Functional Genomics data. Because of the large number of variables measured a comprehensive evaluation of variable subsets cannot be performed with available computational resources. It follows that an efficient variable selection strategy is required. However, although software packages for performing univariate variable selection are available, a comprehensive software environment to develop and evaluate multivariate statistical models using a multivariate variable selection strategy is still needed. In order to address this issue, we developed GALGO, an R package based on a genetic algorithm variable selection strategy, primarily designed to develop statistical models from large-scale datasets.

Citations

Jul 24, 2013·Environmental Science & Technology·Philipp AntczakChris Vulpe
Aug 28, 2007·Bioinformatics·Yvan SaeysPedro Larrañaga
Jan 13, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Adam HinesMark R Viant
Jun 19, 2008·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Fernando OrtegaFrancesco Falciani
Jan 20, 2009·Eukaryotic Cell·Donna M MacCallumFrank C Odds
Mar 4, 2009·Artificial Life·Dafyd J Jenkins, Dov J Stekel
Oct 17, 2009·American Journal of Respiratory and Critical Care Medicine·Florent BatyMartin H Brutsche
Jun 1, 2013·Theoretical Biology & Medical Modelling·Emmanuel Martinez, Victor Trevino
Jul 31, 2007·Molecular Medicine·Victor TrevinoHugo A Barrera-Saldaña
Jul 18, 2014·BMC Systems Biology·Ana Conesa, Ali Mortazavi
Jan 9, 2014·Briefings in Functional Genomics·Tim D WilliamsJ Kevin Chipman
Mar 29, 2014·BMC Bioinformatics·Koen Van der BorghtHerman van Vlijmen
Jun 24, 2014·Sensors·Carlos E Galván-TejadaRamon F Brena
Oct 5, 2010·Computational Biology and Chemistry·Emmanuel MartinezVictor Trevino
Apr 3, 2008·Rapid Communications in Mass Spectrometry : RCM·Wei Zou, Vladimir V Tolstikov
Dec 8, 2010·Proteomics. Clinical Applications·Cedric WiesnerKeith Wilson
Feb 26, 2011·International Journal of Cancer. Journal International Du Cancer·Francis JacobViola Heinzelmann-Schwarz
Aug 15, 2015·Proteomics·Pedro Belda-FerreAlex Mira
Aug 6, 2015·Environmental Science & Technology·Philipp AntczakFrancesco Falciani
Jun 14, 2012·Gene·Loren HansenDavid Landsman
Jun 25, 2015·BioMed Research International·Antonio Martínez-TorteyaJosé G Tamez-Peña
Feb 22, 2017·Diagnostics·Carlos E Galván-TejadaMargarita L Martinez-Fierro
Sep 6, 2019·Sensors·Antonio A AguiletaLuis A Trejo
Sep 20, 2019·BMC Bioinformatics·Alejandro Lopez-RinconAlberto Tonda
Jan 1, 2008·Cancer Informatics·A-L BoulesteixM Daumer
Apr 2, 2016·International Journal of Molecular Medicine·Hugo Gomez-RuedaVictor Trevino
Nov 7, 2015·Journal of Applied Physiology·Peter K DavidsenFrancesco Falciani

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.