PMID: 22569972May 10, 2012Paper

Gallbladder adenocarcinoma: evaluation of the prognostic factors in 100 resectable cases in Brazil

Arquivos Brasileiros De Cirurgia Digestiva : ABCD = Brazilian Archives of Digestive Surgery
Sergio Renato Pais-CostaAlberto Goldenberg

Abstract

In spite its relative rarity, gallbladder adenocarcinoma is a neoplasm who presents an aggressive biologic behavior. The single curative treatment has been radical surgical resection with free margin. Prognostic factors has been studied because are very important to identify long-term survival patients which may benefit of aggressive surgical resection. To evaluate long-term prognostic predictors from gallbladder cancer. The medical records of all patients that presented confirmed histological diagnosis of gallbladder adenocarcinoma operated over a 14 year period were identified and retrospectively reviewed. Uni and multivariate analysis was done. Total sample was 100 patients. Median age was 71 years (34 to 93). There were 17 men and 83 women. Lesion distribution according to TNM stage system was: I (n=22), II (n=59), III (n=6), IV (n=4) and unknown (n=9). Fifty two patients underwent radical resection (R0) while 48 to palliative surgery (R1-R2). Overall major morbidity was 14%, while postoperative surgical mortality rate (30th postoperative day) was 12 %. Five-year survival rate was 28% while median of survival was 10 months. Multivariate analysis identified six prognostic factors: T stage, serum level of CA 19.9, gallbladder...Continue Reading

References

Jan 1, 1994·The British Journal of Surgery·K TsukadaT Muto
Oct 4, 2000·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·A MuratoreL Capussotti
Dec 13, 2002·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·H PuhallaT Gruenberger
Mar 9, 2005·Journal of Hepato-biliary-pancreatic Surgery·Tatsuo AraidaFujio Hanyu
May 18, 2007·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Masahiro KaiKazuhiro Kondo
Dec 1, 2007·Journal of Surgical Oncology·Siu Yin ChanSheung Tat Fan
Feb 16, 2008·Journal of Hepato-biliary-pancreatic Surgery·Tadahiro TakadaUNKNOWN Japan Society of Clinical Oncology
Sep 20, 2008·Journal of Surgical Oncology·A DuffyE M O'Reilly
Oct 25, 2008·Annals of Surgery·Masato KayaharaTetsuo Ohta
Mar 25, 2009·Surgical Oncology Clinics of North America·Srinevas K Reddy, Bryan M Clary
Dec 25, 2009·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Sae Byeol ChoiSang Yong Choi
May 18, 2010·International Journal of Cancer. Journal International Du Cancer·Enriqueta BertranCatterina Ferreccio
May 25, 2010·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Ioannis HatzarasMark Bloomston

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Citations

Jan 21, 2017·Journal of Gastrointestinal Cancer·Sushma AgrawalRajan Saxena
Feb 6, 2020·Revista do Colégio Brasileiro de Cirurgiões·Welligton Ribeiro FigueiredoMarlon Moreno da Rocha Caminha de Paula
Oct 21, 2016·Arquivos Brasileiros De Cirurgia Digestiva : ABCD = Brazilian Archives of Digestive Surgery·Enio Campos AmicoÉlio José Silveira da Silva Barreto
May 20, 2014·Molecular Carcinogenesis·Takuya KitamuraKaoru Kiguchi
Jul 9, 2014·Arquivos Brasileiros De Cirurgia Digestiva : ABCD = Brazilian Archives of Digestive Surgery·Sergio Renato Pais-CostaAlberto Goldenberg

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