Gallbladder Polyps in Metachromatic Leukodystrophy

Fetal and Pediatric Pathology
Saeeda AlmarzooqiAlia Albawardi

Abstract

Metachromatic leukodystrophy (MLD) is an autosomal recessive lysosomal storage disease, caused by a deficiency of arylsulfatase A, and leads to demyelination of the nervous system. A putative association between MLD and gallbladder pathology including malignancy is documented in the medical literature. A 10-year-old boy with MLD was found to have a papillary growth within a cystically dilated gallbladder. The lesion was confirmed to be papillomatosis/polyp with focal intestinal metaplasia. Dysplasia was not identified. MLD may be associated with a spectrum of gallbladder pathology including neoplastic conditions. Pathologists and clinicians should be aware of this association/risk. The patient may be offered regular ultrasound screening of the gallbladder.

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Citations

Mar 27, 2019·Fetal and Pediatric Pathology·Marwa Abdel AzizMona Abdel-Hadi
Dec 13, 2019·Expert Review of Neurotherapeutics·Mahmoud Reza AshrafiAli Reza Tavasoli
Mar 20, 2019·Journal of Pediatric Gastroenterology and Nutrition·Fatma DemirbaşAyhan G Kalayci
Nov 17, 2020·Frontiers in Medicine·Alisa A ShaimardanovaAlbert A Rizvanov

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