Galleria mellonella: An invertebrate model to study pathogenicity in correctly defined fungal species

Fungal Biology
Ulrike BinderCornelia Lass-Flörl

Abstract

The high mortality rates and economic burden associated with fungal infections, plus the emergence of fungal strains resistant to antifungal drugs, make it necessary to get a deeper understanding of fungal pathogenesis, as well as to identify new target structures for antifungal drug development. Still, murine models are considered as the gold standard for studying pathogenesis, quantifying virulence, and analysing the efficacy of antifungal drugs. However, invertebrates, such as the larvae of the greater wax moth Galleria mellonella, are promising alternative hosts to address some of these questions, especially when a large number of fungal strains need to be evaluated. The purpose of this review is to summarize the benefits and drawbacks, explain the utilization of the invertebrate model host G. mellonella, and compare the virulence potential of the most important human fungal pathogens, with the focus on different virulence potential of closely related species.

References

Jan 5, 2000·Applied and Environmental Microbiology·R J St LegerB Shams-Pirzadeh
Jan 21, 2000·FEMS Immunology and Medical Microbiology·G CotterK Kavanagh
Sep 13, 2002·Insect Biochemistry and Molecular Biology·M D Lavine, M R Strand
Nov 11, 2003·Canadian Journal of Microbiology·Gary B DunphyIian Boomer
Feb 21, 2004·FEMS Microbiology Reviews·Kevin Kavanagh, Emer P Reeves
Jun 24, 2005·Infection and Immunity·Eleftherios MylonakisAndrew Diener
Feb 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Leah E CowenSusan Lindquist
Sep 30, 2009·Insect Biochemistry and Molecular Biology·Susan E BrownPeter D East
Mar 13, 2010·Microbes and Infection·Beth Burgwyn FuchsEleftherios Mylonakis
Mar 24, 2010·Infection and Immunity·Chun-Cheih ChaoYung-Jen Chuang
Jun 19, 2010·Developmental and Comparative Immunology·Pawel MakMałgorzata Cytryńska
Sep 8, 2010·Medical Mycology·Manjinder S Cheema, Julian K Christians
Nov 11, 2010·Molecular Microbiology·Hong LiuScott G Filler
Dec 15, 2010·Fungal Genetics and Biology : FG & B·Rebecca R AchtermanTheodore C White
Dec 24, 2010·Virulence·Beth Burgwyn FuchsEleftherios Mylonakis
Jun 24, 2011·PLoS Pathogens·Charles H LiSoo Chan Lee
Sep 13, 2011·Fungal Genetics and Biology : FG & B·Gesabel Y Navarro-VelascoAntonio Di Pietro
Nov 26, 2011·Fungal Biology·Jeffrey J ColemanEleftherios Mylonakis
Jan 4, 2012·The American Journal of Medicine·Michael A Pfaller
Apr 21, 2012·International Journal of Microbiology·Georgios HamilosDimitrios P Kontoyiannis
Jul 24, 2013·Antimicrobial Agents and Chemotherapy·A ForastieroE Mellado
Sep 3, 2013·Biological & Pharmaceutical Bulletin·De-Dong LiYan Wang
Feb 25, 2014·Journal of Insect Physiology·Niall BrowneKevin Kavanagh
May 23, 2014·Virulence·Helene C EisenmanErin E McClelland
Aug 13, 2014·The Journal of Infectious Diseases·Athanasios DesalermosEleftherios Mylonakis
Oct 14, 2014·European Journal of Histochemistry : EJH·F PerdoniE Borghi

❮ Previous
Next ❯

Citations

Feb 24, 2016·Drug Discoveries & Therapeutics·Masaki IshiiKazuhisa Sekimizu
Nov 9, 2016·Microbiological Research·Aneta Sowa-JasiłekMałgorzata Cytryńska
Jun 24, 2017·Medical Mycology·Liliana ScorzoniMaria José Soares Mendes-Giannini
Jan 27, 2018·Mycobiology·Hadeel Saeed Al-MalikiJoan W Bennett
Nov 8, 2018·The Journal of Antimicrobial Chemotherapy·Rogelio de J Treviño-RangelGloria M González
Mar 1, 2019·Acta Microbiologica Et Immunologica Hungarica·Pantira SingkumNatthanej Luplertlop
Nov 11, 2019·Journal of Applied Microbiology·F C RibeiroJ C Junqueira
Mar 10, 2017·Gut Microbes·Shoshana BarnoyMalabi M Venkatesan
May 19, 2019·Scientific Reports·Vicent Llopis-TorregrosaHana Sychrová
Feb 14, 2019·Medical Mycology·Yinghui LiuChester R Cooper
Nov 30, 2018·Journal of Fungi·Thais Cristine PereiraLiliana Scorzoni
Apr 3, 2019·Journal of Fungi·Ilse D Jacobsen
Dec 24, 2019·Frontiers in Cellular and Infection Microbiology·Junya de Lacorte SingulaniMaria José Soares Mendes Giannini
Feb 9, 2021·Frontiers in Cellular and Infection Microbiology·Nathália Ferreira FregoneziAna Marisa Fusco-Almeida
Mar 9, 2021·Virulence·Marie-Fleur DurieuxFrançoise Botterel
May 1, 2021·Pathogens·Martyna Mroczyńska, Anna Brillowska-Dąbrowska
Mar 10, 2019·Biochimica Et Biophysica Acta. Proteins and Proteomics·Brian C MonkMikhail V Keniya
Dec 1, 2017·Medical Mycology Journal·Yasuhiko MatsumotoKazuhisa Sekimizu
May 27, 2021·Studies in Mycology·A ArastehfarM Hoenigl

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.