Gallic acid ameliorates renal functions by inhibiting the activation of p38 MAPK in experimentally induced type 2 diabetic rats and cultured rat proximal tubular epithelial cells

Chemico-biological Interactions
Amjid AhadWaseem Ahmad Siddiqui

Abstract

Diabetic nephropathy (DN) is one of the leading causes of morbidity and mortality in diabetic patients that accounts for about 40% of deaths in type 2 diabetes. p38 mitogen activated protein kinase (p38 MAPK), a serine-threonine kinase, plays an important role in tissue inflammation and is known to be activated under conditions of oxidative stress and hyperglycemia. The role of p38 MAPK has been demonstrated in DN, and its inhibition has been suggested as an alternative approach in the treatment of DN. In the present study, we investigated the nephroprotective effects of an anti-inflammatory phenolic compound, gallic acid (GA, 3,4,5-trihydroxybenzoic acid), in high fat diet/streptozotocin (HFD/STZ) induce type 2 diabetic wistar albino rats. GA (25 mg/kgbw and 50 mg/kgbw, p.o.) treatment for 16 weeks post induction of diabetes led to a significant reduction in the levels of blood glucose, HbA1c, serum creatinine, blood urea nitrogen and proteinuria as well as a significant reduction in the levels of creatinine clearance. GA significantly inhibited the renal p38 MAPK and nuclear factor kappa B (N-κB) activation as well as significantly reduced the levels of renal transforming growth factor beta (TGF-β) and fibronectin. Treatment ...Continue Reading

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Citations

Jul 5, 2016·International Journal of Molecular Sciences·Shudong WangYang Zheng
Jul 19, 2016·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Chenxue ZhangYang Yu
Oct 22, 2016·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Jinyang ShenChangrun Guo
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Jul 12, 2019·Heliyon·Ahmad GhorbaniAzar Hosseini
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Jul 20, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Adel Abdel-MoneimMohamed B Ashour

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