Gallic acid and MiADMSA reversed arsenic induced oxidative/nitrosative damage in rat red blood cells

Heliyon
Archna PanghalS J S Flora

Abstract

Arsenic (As) is naturally occurring toxic metalloid which is considered as a serious environmental and health concern. Red blood cells are the prime target for any toxicants as their population is higher in systemic circulation. High prevalence of anaemia too has been reported from arsenic contaminated area, suggesting possible linkage between arsenic and the damaging effects on RBCs. The exact mechanism for these effects is still not clear, however, oxidative/nitrosative stress might be one of the causative factors to play a key role. The present study was planned to evaluate the protective effects of a metal chelator, MiADMSA either alone or in combination with a natural antioxidant (gallic acid) for the reversal of arsenic induced oxidative damage in red blood cells. We collected rat RBCs and cultured them in appropriate medium. They were incubated with MiADMSA and gallic acid and then treated with sodium arsenite at 37 °C. Hemolysates were prepared and assayed for various biochemical parameters such as oxidative/nitrosative variables, osmotic fragility, acetylcholinesterase activity, and cellular metal accumulation. We found there was reversibility of oxidative/nitrosative stress variables, elevated cellular antioxidant pow...Continue Reading

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Citations

May 1, 2020·Antioxidants·Rossana MorabitoAngela Marino
Sep 21, 2020·Environmental Science and Pollution Research International·Chetan RajakPoonam Parashar

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Methods Mentioned

BETA
blood drawn
atomic absorption spectroscopy
MDA

Software Mentioned

Graph Pad ( Prism
Microsoft manager

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