Gallic acid protects against the COPD-linked lung inflammation and emphysema in mice

Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]
Esha SinglaAmarjit S Naura

Abstract

Gallic acid (GA) a naturally occurring phenolic compound, known to possess antioxidant/anti-inflammatory activities. The aim of the present work was to investigate the beneficial effects of GA against COPD-linked lung inflammation/emphysema by utilizing elastase (ET) and cigarette smoke (CS)-induced mice model. Male BALB/c mice were treated with ET (1U/mouse) or exposed to CS (9 cigarettes/day for 4 days). GA administration was started 7 days (daily) prior to ET/CS exposure. Broncho-alveolar lavage was analyzed for inflammatory cells and pro-inflammatory cytokines. Lung homogenate was assessed for MPO activity/GSH/MDA/protein carbonyls. Further, Lung tissue was subjected to semi-quantitative RT-PCR, immunoblotting, and histological analysis. GA suppressed the ET-induced neutrophil infiltration, elevated MPO activity and production of pro-inflammatory cytokines (IL-6/TNF-α/IL-1β) at 24 h. Reduced inflammation was accompanied with normalization of redox balance as reflected by ROS/GSH/MDA/protein carbonyl levels. Further, GA suppressed phosphorylation of p65NF-κB and IκBα along with down-regulation of IL-1β/TNF-α/KC/MIP-2/GCSF genes. Furthermore, GA offered protection against ET-induced airspace enlargement and ameliorated MMP-2/...Continue Reading

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Citations

Sep 24, 2020·Molecular and Cellular Biochemistry·Esha SinglaAmarjit S Naura
Nov 20, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Jinrong BaiXianli Meng
Jun 4, 2021·Environmental Science and Pollution Research International·Farzaneh SohrabiSeyyed Ali Mard
Sep 28, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Milad AshrafizadehRajender S Varma

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Methods Mentioned

BETA
PCR
lavage
MDA

Software Mentioned

GraphPad
pad prism
Graph
ImageJ

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