Gallstone dissolution treatment with a combination of chenodeoxycholic and ursodeoxycholic acids. Studies of safety, efficacy and effects on bile lithogenicity, bile acid pool, and serum lipids

Digestive Diseases and Sciences
R RoehrkasseS Ceryak

Abstract

Sixteen patients with radiolucent gallstones were treated with a combination of chenodeoxycholic and ursodeoxycholic acids for an average of 19 months. Liver tests remained normal in all patients. In nine of 15 patients (60%), in whom the gallbladder visualized during an oral cholecystogram, gallstones dissolved after one year, in eight of them, partially, and in the remaining one, completely. After two years, partial dissolution became complete in three patients, and partial dissolution occurred in 1 additional patient. Changes in lithogenic index and bile acid pool size were statistically not significant. Biliary content of chenodeoxycholic acid increased significantly from 25.7 +/- 3.53 to 45.2 +/- 3.31 (mean +/- SE)% and that of ursodeoxycholic acid from 2.6 +/- 0.52 to 34.6 +/- 2.45%. There were no discernible changes in serum triglycerides, total cholesterol, and HDL cholesterol. The findings suggest that the chenodeoxycholic-ursodeoxycholic acid combination provides a safe and efficacious treatment for some cholesterol gallstones.

References

Aug 8, 1975·Deutsche medizinische Wochenschrift·H FrommF W Schmidt
Mar 13, 1978·JAMA : the Journal of the American Medical Association·J L ThistleD H Stephens
Jan 24, 1985·The New England Journal of Medicine·M J AllenJ L Thistle
Dec 17, 1974·Clinica Chimica Acta; International Journal of Clinical Chemistry·E W Pomare, T S Low-Beer
Jun 1, 1973·The Journal of Clinical Investigation·R T HolzbachK Holan
Jan 6, 1972·The New England Journal of Medicine·R G DanzingerJ L Thistle
Apr 1, 1971·Zeitschrift für Ernährungswissenschaft·F G Hegardt, H Dam
Dec 1, 1983·Antimicrobial Agents and Chemotherapy·L J EronD M Poretz
Sep 5, 1981·British Medical Journal·M C BatesonT C Northfield
Sep 1, 1982·Annals of Internal Medicine·G S TintS Shefer
Aug 1, 1982·Digestive Diseases and Sciences·W H Bachrach, A F Hofmann
Nov 1, 1982·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·E RodaL Barbara

❮ Previous
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Citations

May 1, 1994·Digestive Diseases and Sciences·J Y SungJ W Costerton
Nov 1, 1992·Baillière's Clinical Gastroenterology·H Fromm, M Malavolti
Apr 1, 1988·Zeitschrift für Gastroenterologie. Verhandlungsband·G PaumgartnerT Sauerbruch
Nov 1, 1989·Annals of Surgery·H VergunstF H Schröder
Jul 29, 1989·BMJ : British Medical Journal·A DarziF B Keane
Sep 1, 1989·American Journal of Surgery·A F Hofmann
Jul 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M Borum, H Fromm
Sep 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S M Strasberg, P A Clavien
Dec 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M SackmannG Paumgartner
Feb 1, 1991·The British Journal of Surgery·S Cheslyn-Curtis, R C Russell
Jan 1, 1993·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·B I CohenT Hoshita
May 10, 2005·European Journal of Gastroenterology & Hepatology·Thomas RabensteinHans T Schneider
Jan 1, 1994·Scandinavian Journal of Gastroenterology. Supplement·G PaumgartnerM Sackmann
Feb 18, 1988·The New England Journal of Medicine·M SackmannW Brendel
Apr 1, 1993·Alimentary Pharmacology & Therapeutics·G R MayE A Shaffer
Jun 1, 1989·Alimentary Pharmacology & Therapeutics·J A Summerfield
Nov 1, 1990·Current Problems in Surgery·J B PrystowskyR V Rege

❮ Previous
Next ❯

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