PMID: 3758942Sep 1, 1986Paper

Gallstone prevention in prairie dogs: comparison of chow vs. semisynthetic diets

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
B I CohenB Rzigalinski

Abstract

The effects of a standard rodent chow were compared with those of a semisynthetic diet of known composition (with and without added cholesterol) in the prairie dog model of cholesterol cholelithiasis. Gallstone incidence was 40% higher in animals fed a semisynthetic diet plus cholesterol compared to chow plus cholesterol. The semisynthetic diet plus cholesterol caused significant increases in tissue cholesterol levels (serum, liver and bile) and lithogenic index, but significant decreases in the activity of hepatic 3-hydroxy-3-methyl-glutaryl coenzyme A reductase and cholesterol 7 alpha-hydroxylase compared to chow plus cholesterol. Histologic study of liver sections revealed that the semisynthetic diet plus cholesterol resulted in moderate to marked portal tract changes characterized by bile duct proliferation, inflammatory infiltration and fibrosis, whereas the cholesterol-supplemented chow diet caused only slight bile duct proliferation with minimal inflammation and fibrosis in the portal areas. Dietary hyodeoxycholic acid prevented cholesterol gallstones and biliary cholesterol crystals when added to either chow plus cholesterol or semisynthetic plus cholesterol diets. The hyodeoxycholic acid supplements also prevented the ...Continue Reading

References

Oct 1, 1978·The American Journal of Clinical Nutrition·K K CarrollA D Falconer
Mar 1, 1976·Canadian Journal of Biochemistry·J J KimK K Carroll
Jan 1, 1985·American Journal of Surgery·C K McSherryA K Singhal
Jun 1, 1972·The Journal of Clinical Investigation·D E BrennemanL DenBesten
Mar 1, 1984·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·B I CohenE H Mosbach

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Citations

Jun 10, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A F AttiliD Festi
Oct 12, 2013·World Journal of Gastroenterology : WJG·Adnan Adil HismiogullariKhalid Rahman
Jul 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J G PauletzkiE A Shaffer
Jul 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·B I CohenR J Stenger

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