Gallstones in children with sickle cell disease followed up at a Brazilian hematology center

Arquivos De Gastroenterologia
Ana Paula dos Santos GumieroElizete Aparecida Lomazi da Costa-Pinto

Abstract

Sickle cell disease causes chronic and recurrent hemolysis which is a recognized risk factor for cholelithiasis. This complication occurs in 50% of adults with sickle cell disease. Surgery is the consensual therapy for symptomatic patients, but the surgical approach is still controversial in asymptomatic individuals. To determine the frequency and to describe and discuss the outcome of children with sickle cell disease complicated with gallstones followed up at a tertiary pediatric hematology center. In a retrospective and descriptive study, 225 charts were reviewed and data regarding patient outcome were recorded. The prevalence of cholelithiasis was 45% and half the patients were asymptomatic. The mean age at the time of diagnosis of cholelithiasis and surgical treatment was 12.5 years (standard deviation = 5) and 14 years (standard deviation = 5.4), respectively. The prevalence of cholelithiasis was higher in patients with SS homozygous and Sb heterozygous thalassemia when compared to patients with sickle cell disease. In 50% of symptomatic patients, recurrent abdominal pain was the single or predominant symptom. Thirty-nine of 44 patients submitted to surgery reported symptom relief after the surgical procedure. Asymptomati...Continue Reading

References

Jan 1, 1989·Pediatric Radiology·D A Nzeh, M A Adedoyin
Jul 1, 1988·American Journal of Diseases of Children·B S Malone, S L Werlin
Nov 1, 1994·The Journal of Pediatrics·S S WinterR E Ware
Sep 1, 1996·The Journal of Pediatrics·T M Walker, G R Serjeant
Jan 31, 1998·Pediatric Surgery International·A H Al-Salem, S Qaisruddin
Jan 15, 2000·The Journal of Pediatrics·T M WalkerG R Serjeant
Feb 15, 2002·Current Opinion in Hematology·Dapa Diallo, Gil Tchernia
Jun 13, 2003·Pediatric Radiology·Marina G PapadakiChristos A Kattamis
Nov 3, 2004·The Journal of Pediatrics·Mary Nell SuellBrigitta U Mueller

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Citations

Dec 15, 2010·Indian Pediatrics·Ujjal Poddar
Jun 10, 2011·Saudi Journal of Anaesthesia·Saswata BharatiSubrata Mandal
May 12, 2012·World Journal of Gastrointestinal Pharmacology and Therapeutics·Piero PortincasaDavid Qh Wang
Nov 13, 2015·Expert Review of Gastroenterology & Hepatology·P PortincasaD Q-H Wang
Jul 18, 2012·Seminars in Pediatric Surgery·Jan Svensson, Erica Makin
May 19, 2010·Gastroenterology Clinics of North America·Kurinchi S Gurusamy, Brian R Davidson
Dec 21, 2012·Pediatric Blood & Cancer·Martha O AmoakoJohn J Strouse
Aug 16, 2016·Seminars in Pediatric Surgery·David H Rothstein, Carroll M Harmon
Jan 6, 2012·Pediatric Emergency Care·Cori McClure PoffenbergerRichard Renslo
Nov 20, 2013·Journal of Clinical Gastroenterology·Melissa M RhodesJolanda M Denham
Jun 7, 2011·Pediatric Emergency Care·Dana Aronson SchinasiRakesh Mistry
Sep 20, 2016·Pediatric Blood & Cancer·Emily F GoodwinThomas H Howard
Jul 22, 2021·Arquivos De Gastroenterologia·Lucas Rocha AlvarengaMaria Ângela Bellomo-Brandão

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