PMID: 9187329May 9, 1997Paper

Galparan induces in vivo acetylcholine release in the frontal cortex

Brain Research
S ConsoloT Bartfai

Abstract

The chimeric peptide galparan (galanin(1-13)-mastoparan) induced the in vivo release of acetylcholine in the frontal cortex of rats when injected intracerebroventricularly, i.c.v. The ACh-releasing effects of galparan are reversible, dose-dependent, and not exerted at galanin receptors or at sites where mastoparan acts. Pertussis toxin pretreatment (i.c.v.) of the rats for 96 h prior to injection of galparan or of mastoparan completely prevented the ACh-releasing effects of both galparan and mastoparan. It appears that galparan acts at a novel site in the release of ACh in the cerebral cortex in vivo.

Citations

Feb 3, 1999·Annals of the New York Academy of Sciences·M PoogaU Langel
Jan 23, 1998·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·M PoogaU Langel
Feb 4, 1998·Archives of Biochemistry and Biophysics·M ZorkoU Langel

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