PMID: 9450684Feb 5, 1998Paper

GALR1 galanin receptor mRNA is co-expressed by galanin neurons but not cholinergic neurons in the rat basal forebrain

Brain Research. Molecular Brain Research
M A MillerM A Raskind

Abstract

The neuropeptide galanin (GAL) has been proposed to be an inhibitory modulator of cholinergic transmission in the hippocampus and may impair memory by directly affecting the activity of basal forebrain (BF) cholinergic neurons. Alternatively, GAL may act indirectly and modulate the activity of other neurotransmitter systems which, in turn, influence cholinergic transmission. We have used double in situ hybridization histochemistry to evaluate the co-expression of the GAL receptor subtype, GALR1, within cholinergic neurons in the medial septum/diagonal band of adult male rats. In alternate brain sections, we assessed the co-expression of GALR1 mRNA within another forebrain cell group implicated in memory functions, the neurons of the bed nucleus of the stria terminalis (BNST) and medial amygdala (AMe) which co-express vasopressin (VP) and GAL and project to septo-hippocampus. Despite the abundance of GALR1 mRNA-expressing neurons in the cholinergic BF, we found no evidence for the co-expression of this receptor subtype within cholinergic neurons in the medial septum/diagonal band. In contrast, we detected an extensive co-expression (95%) of GALR1 mRNA within extrahypothalamic VP/GAL neurons. These results do not support the idea...Continue Reading

References

Nov 1, 1992·Neuroscience·S O OgrenT Bartfai
Jan 1, 1992·Life Sciences·D H MalinJ R Lake
Jun 5, 1992·Brain Research·B S GivensJ N Crawley
Oct 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·G FisoneT Hökfelt
Dec 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·J MastropaoloJ N Crawley
Jul 15, 1987·Experientia·T HökfeltT Bartfai
Jul 8, 1987·The Journal of Comparative Neurology·A R CafféP G Luiten
Mar 8, 1985·The Journal of Comparative Neurology·G J DeVriesD F Swaab
Jun 15, 1984·Neuroscience Letters·A RökaeusV Mutt
Aug 16, 1994·Proceedings of the National Academy of Sciences of the United States of America·S ConsoloA Vezzani
Oct 1, 1994·Behavioral Neuroscience·J K Robinson, J N Crawley
Jan 1, 1993·Progress in Neuro-psychopharmacology & Biological Psychiatry·J K Robinson, J N Crawley
Jun 1, 1993·Progress in Neurobiology·I MerchenthalerA Negro-Vilar
Oct 31, 1994·Annals of the New York Academy of Sciences·P L Hoffman
Dec 1, 1993·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·M A MillerM A Raskind
Jan 4, 1994·Proceedings of the National Academy of Sciences of the United States of America·Z WangG J De Vries
Jul 22, 1993·Annals of the New York Academy of Sciences·B BohusB Roozendaal

❮ Previous
Next ❯

Citations

Dec 29, 1999·Brain Research·S O OgrenH Razani
Feb 3, 1999·Annals of the New York Academy of Sciences·E J MufsonD C Deecher
Feb 3, 1999·Annals of the New York Academy of Sciences·M A Miller
May 20, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Estefanía MorenoSergi Ferré
Nov 15, 2011·Journal of Neuroimmunology·Alfredo CostaSergueï O Fetissov
Aug 9, 2016·Brain Structure & Function·Joanne C DamborskyJerrel L Yakel
Feb 3, 1999·Annals of the New York Academy of Sciences·T BranchekM W Walker
Apr 7, 2005·Behavioral and Cognitive Neuroscience Reviews·John K Robinson
May 2, 2001·The Journal of Comparative Neurology·S E PérezE J Mufson

❮ Previous
Next ❯

Related Concepts

Related Feeds

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

Basal Forebrain- Circuits

Basal forebrain is a region in the brain important for production of acetylcholine and is the major cholinergic output of the CNS. Discover the latest research on circuits in the basal forebrain here.

Basal Forebrain & Food Avoidance

Neurons in the basal forebrain play specific roles in regulating feeding. Here are the latest discoveries pertaining to the basal forebrain and food avoidance.

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.