PMID: 22339063Feb 22, 2012Paper

Gambogic acid is a novel anti-cancer agent that inhibits cell proliferation, angiogenesis and metastasis

Anti-cancer Agents in Medicinal Chemistry
Xu Wang, Wantao Chen

Abstract

Gambogic acid (GA) is a caged xanthone that is derived from Garcinia hanburyi and functions as a strong apoptotic inducer in many types of cancer cells. The distinct effectiveness of GA has led to its characterization as a novel anti-cancer agent. There is an increasing number of research studies focused on elucidating the molecular mechanisms of GA-induced anti-cancer effects, and several critical signaling pathways have been reported to be influenced by GA treatment. In this review, we summarize the multiple functional effects of GA administration in cancer cells including the induction of apoptosis, the inhibition of proliferation and the prevention of cancer metastasis and tumor angiogenesis.

Citations

Jun 27, 2012·Biochemical and Biophysical Research Communications·Baobing ZhaoYuemao Shen
Dec 30, 2014·Journal of Experimental & Clinical Cancer Research : CR·Zhongjing LvWanTao Chen
Sep 27, 2015·International Journal of Pharmaceutics·Shengpeng WangMeiwan Chen
Apr 14, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Yong-Zhan ZhenGang Hu
Jan 31, 2015·PLoS Neglected Tropical Diseases·Cristiana LalliGiovina Ruberti
Jul 23, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Dharambir KashyapAnil K Sharma
Oct 19, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Li ZhangHong-Xi Xu
May 15, 2015·Scientific Reports·Xiaoyu WangHongxi Xu
Oct 12, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jingya RuanTao Wang
Dec 12, 2018·Current Drug Targets·Vinayak NarayanankuttyAnusree Nair
Jan 1, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Guo-Xuan LuoYong Zhang
Dec 4, 2019·Chemistry & Biodiversity·Luiz C Klein-JúniorValdir Cechinel Filho
Jul 8, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Li QiaoQingcong Wei
Mar 17, 2018·Naunyn-Schmiedeberg's Archives of Pharmacology·Mаhmoud YounsRehab Kamel
Sep 27, 2019·Experimental and Therapeutic Medicine·Zailong Zhou, Jian Ma

❮ Previous
Next ❯

Related Concepts

Related Feeds

Angiogenesis Inhibitors to Treat Cancer

Cancer treatments including angiogenesis inhibitors prevent tumor cells from receiving nutrients and oxygen. Here is the latest research on angiogenesis inhibitors for the treatment of cancer.