Gametocyte Carriage, Antimalarial Use, and Drug Resistance in Cambodia, 2008-2014

The American Journal of Tropical Medicine and Hygiene
Jessica T LinChanthap Lon

Abstract

Gametocytes are the malaria parasite stages responsible for transmission from humans to mosquitoes. Gametocytemia often follows drug treatment, especially as therapies start to fail. We examined Plasmodium falciparum gametocyte carriage and drug resistance profiles among 824 persons with uncomplicated malaria in Cambodia to determine whether prevalent drug resistance and antimalarial use has led to a concentration of drug-resistant parasites among gametocyte carriers. Although report of prior antimalarial use increased from 2008 to 2014, the prevalence of study participants presenting with microscopic gametocyte carriage declined. Gametocytemia was more common in those reporting antimalarial use within the past year, and prior antimalarial use was correlated with higher IC50s to piperaquine and mefloquine, as well as to increased pfmdr1 copy number. However, there was no association between microscopic gametocyte carriage and parasite drug resistance. Thus, we found no evidence that the infectious reservoir, marked by those carrying gametocytes, is enriched with drug-resistant parasites.

References

Jul 14, 1999·The American Journal of Tropical Medicine and Hygiene·R PriceN J White
Jun 13, 2006·Transactions of the Royal Society of Tropical Medicine and Hygiene·C T LonA Smine
Dec 20, 2013·Nature·Frédéric ArieyDidier Ménard
Jul 31, 2014·The New England Journal of Medicine·Elizabeth A AshleyUNKNOWN Tracking Resistance to Artemisinin Collaboration (TRAC)
Oct 1, 2014·Malaria Journal·Richard J MaudeChar Meng Chuor
Dec 17, 2015·The Journal of Infectious Diseases·Jessica T LinDavid L Saunders
Sep 1, 2017·Genome Biology and Evolution·Christian M ParobekJonathan J Juliano

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Citations

Feb 27, 2020·The American Journal of Tropical Medicine and Hygiene·Mario J OliveraAlexandre Macedo de Oliveira

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