PMID: 5914762Oct 14, 1966

Gamma-A cold agglutinin: importance of disulfide bonds in activity and structure

B R Andersen


Cleavage of disulfide bonds caused by mild reduction with mercaptoethanol produces a reversible loss of cold agglutinin activity and antigen-binding ability in a gamma-A polymer cold agglutinin. Return of agglutination and antigen-binding ability occur only in those molecules that have not been depolyimerized by reduction. Loss of activity becomes irreversible if reduction is followed immediately by alkylation.


Dec 31, 1971·Annals of the New York Academy of Sciences·R C Williams
Mar 1, 1975·The American Journal of Medicine·J L Moake, D R Schultz
Jan 1, 1974·Clinical Immunology and Immunopathology·D Roelcke

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