PMID: 32538Dec 1, 1978Paper

gamma-Aminobutyric acid: a neurotransmitter candidate for cone horizontal cells of the catfish retina

Proceedings of the National Academy of Sciences of the United States of America
D M LamK I Naka

Abstract

In the catfish retina, horizontal cells that receive inputs exclusively from red-sensitive cones are the only neurons that accumulate exogenous gamma-aminobutyric acid under our experimental conditions. When isolated eyecups are perfused with bicuculline methochloride, an antagonist of postsynaptic gamma-aminobutyric acid receptors, responses of cone photoreceptors to a field of light (3 mm in diameter) become much slower and approach those to a small spot of light (0.3 mm). In addition, bicuculline methochloride decreases the frequency responses of cone horizontal cells to a field of light. These findings indicate that, in the catfish retina, feedback synapses from cone horizontal cells to cones are chemically mediated and may use gamma-aminobutyric acid as a neurotransmitter. Our results also confirm the hypothesis that, in the catfish retina, a function of the negative feedback is to improve the frequency responses of the system.

References

Jan 1, 1976·Cold Spring Harbor Symposia on Quantitative Biology·D M Lam
Nov 15, 1978·The Journal of Comparative Neurology·R E MarcD M Lam
Feb 15, 1975·The Journal of Comparative Neurology·W K Stell, D O Lightfoot
Feb 15, 1975·The Journal of Comparative Neurology·W K Stell
Apr 1, 1972·Vision Research·K I Naka
Dec 13, 1972·Nature: New Biology·G A JohnstonR M Maclachlan
Nov 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·D M Lam, L Steinman

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Citations

Sep 25, 1981·Molecular and Cellular Biochemistry·J Y WuD M Lam
Sep 28, 1981·Brain Research·S L Stone, R L Chappell
Mar 19, 1984·Brain Research·A BruunV M Sytsma
Apr 23, 1984·Brain Research·R Weiler, H J Wagner
Jan 1, 1982·Vision Research·K I Naka
Jan 1, 1983·Vision Research·G L FainS Callery
Jan 1, 1983·Vision Research·H Kondo, J Toyoda
Jan 1, 1985·Vision Research·M YamadaM Fuwa
Jan 1, 1980·Neurochemistry International·D M LamJ Y Wu
Feb 1, 1992·Neurochemistry International·M B Djamgoz, H J Wagner
Jan 1, 1987·Progress in Neurobiology·S C Massey, D A Redburn
Jan 1, 1985·Neuroscience Research. Supplement : the Official Journal of the Japan Neuroscience Society·A Takabayashi, G Mitarai
May 1, 1992·Visual Neuroscience·E Van Haesendonck, L Missotten
Jan 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·S Yazulla, N Brecha
Jun 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·M PiccolinoH M Gerschenfeld
Dec 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·M Tachibana, A Kaneko
Nov 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·R P Malchow, H Ripps
Aug 1, 1981·The Journal of Cell Biology·E A Schwartz
Jan 1, 1982·The Journal of General Physiology·J Toyoda, T Kujiraoka
Sep 1, 1985·The Journal of General Physiology·R L ChappellM Sakuranaga
Feb 1, 1987·The Journal of General Physiology·K I NakaR L Chappell
Jul 1, 1979·Journal of Neurochemistry·Y Y SuD M Lam
Sep 28, 2014·Journal of Computational Neuroscience·Carl L GardnerSharon M Crook
Jun 6, 1998·The Journal of Physiology·O Umino, T Ushio
Oct 20, 1980·Brain Research·S M Wu, J E Dowling

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