Gamma-aminobutyric acid A receptor, α-2 (GABRA2) variants as individual markers for alcoholism: a meta-analysis

Psychiatric Genetics
Elias Zintzaras

Abstract

The available evidence from the genetic association studies (GAS) published to date on the association between variants in the GABRA2 gene and alcoholism has produced inconclusive results. To interpret these results, a meticulous meta-analysis of all available studies was carried out. The PubMed database and the HuGE Navigator were searched for published GAS-related variants in the GABRA2 gene with susceptibility to alcoholism. Then, the GAS were synthesized to decrease the uncertainty of estimated genetic risk effects. The risk effects were estimated on the basis of the odds ratio (OR) of the allele contrast and the generalized odds ratio (OR(G)), a model-free approach. Cumulative and recursive cumulative meta-analyses (CMA) were also carried out to investigate the trend and stability of effect sizes as evidence accumulates. Fourteen variants investigated in eight studies were analyzed. Significant associations were derived for four variants either for the allele contrast or for the OR(G). In particular, the variants rs279858 and rs279845 showed marginal significance for OR(G): OR(G)=1.27 (1.01-1.60) and OR(G)=1.49 (1.02-2.19), respectively. Also, the variants rs567926 and rs279844 showed significance for the allele contrast: ...Continue Reading

References

Jul 23, 1992·The New England Journal of Medicine·J LauT C Chalmers
Sep 1, 1986·Controlled Clinical Trials·R DerSimonian, N Laird
Aug 1, 1981·Archives of General Psychiatry·C R CloningerS Sigvardsson
Oct 13, 1998·Psychopharmacology·A C GrobinA L Morrow
Nov 18, 1998·Archives of General Psychiatry·D Goldman, A Bergen
Dec 26, 2001·Archives of General Psychiatry·K S Kendler
Sep 11, 2003·Annals of Internal Medicine·Richard S Cooper
Feb 21, 2004·BMC Genetics·Diego F WyszynskiLindsay A Farrer
Jul 27, 2004·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Jonathan CovaultHenry R Kranzler
Dec 9, 2004·Pharmacogenomics·Gabor Oroszi, David Goldman
Apr 19, 2005·Alcoholism, Clinical and Experimental Research·Jaakko LappalainenJoel Gelernter
Dec 14, 2005·Statistics in Medicine·Roger M HarbordJonathan A C Sterne
Feb 3, 2006·BMC Genetics·Xiaofeng ZhuXiaodong Wu
Mar 17, 2006·Current Psychiatry Reports·Danielle M Dick, Laura J Bierut
Mar 28, 2006·Journal of Studies on Alcohol·Danielle M DickHenri Begleiter
Aug 9, 2006·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Tomas DrgonGeorge R Uhl
Sep 12, 2006·Addiction Biology·Howard J Edenberg, Tatiana Foroud
Jan 9, 2007·Journal of Psychiatric Research·M SoykaB Bondy
Nov 9, 2007·Computational Biology and Chemistry·Elias Zintzaras, John P A Ioannidis
Dec 12, 2007·Journal of Human Genetics·Elias Zintzaras, Joseph Lau
Mar 25, 2008·Advances in Genetics·Thomas A TrikalinosJohn P A Ioannidis
Apr 29, 2008·Pharmacology, Biochemistry, and Behavior·Mary-Anne Enoch
Aug 30, 2008·Alcoholism, Clinical and Experimental Research·Penelope A LindJohn B Whitfield
Sep 27, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Mary-Anne EnochDavid Goldman
Jul 8, 2009·Archives of General Psychiatry·Jens TreutleinMarcella Rietschel
Jul 17, 2009·Annals of Human Genetics·Georgios D Kitsios, Elias Zintzaras
Aug 13, 2009·Psychiatric Genetics·Robert A PhilibertWilliam Adams
Jan 28, 2010·Alcoholism, Clinical and Experimental Research·Nicoletta OnoriAdriano Tagliabracci
Mar 6, 2010·Alcoholism, Clinical and Experimental Research·Howard J EdenbergTatiana Foroud
Mar 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·Laura J BierutUNKNOWN Gene, Environment Association Studies Consortium

❮ Previous
Next ❯

Citations

Dec 7, 2013·World Journal of Gastroenterology : WJG·Sonia RomanArturo Panduro
Aug 4, 2015·Current Addiction Reports·Jessica E SalvatoreDanielle M Dick
Mar 28, 2017·Pharmacogenomics·Jennifer A Rinker, Patrick J Mulholland
Feb 13, 2018·Policy Insights From the Behavioral and Brain Sciences·Jeanne E SavageJessica E Salvatore
Oct 19, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Dawei LiJoel Gelernter
Aug 12, 2016·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Judit DiószegiRóza Ádány
Dec 17, 2014·Journal of Clinical Psychopharmacology·Clement C H ZaiJames L Kennedy
Dec 31, 2019·Genetics Research International·Vitalina BashynskaAlexander Vaiserman
Jun 29, 2016·Neuroscience and Biobehavioral Reviews·Jessica E Salvatore, Danielle M Dick

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Nature Reviews. Gastroenterology & Hepatology
Howard J Edenberg, Tatiana Foroud
Journal of Neural Transmission
Christoph FehrUlrich W Preuss
Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases
Tian TianGuangzhong Li
© 2021 Meta ULC. All rights reserved