Gamma-aminobutyric acid and afferent inhibition in the cat and rat ventrobasal thalamus

Neuroscience
T E Salt

Abstract

Extracellular single neuron recordings were made in the ventrobasal thalami of anaesthetized rats and cats. Physiological stimulation of vibrissa and hair follicle afferents was performed with an air jet (10-20 ms duration) directed at a single vibrissa or small area of hairy skin. Paired conditioning and test air jets delivered to the excitatory portion of receptive fields revealed inhibition of the response of ventrobasal thalamic neurons to test stimuli following the excitatory response to the conditioning stimulus. Such inhibitions could last up to 500 ms. An increase in neuronal excitability was sometimes observed following this inhibitory period. In addition, it was possible to produce inhibition without an excitatory response using conditioning stimuli delivered adjacent to the excitatory receptive field. Iontophoretic application of bicuculline methochloride, with currents that were adequate to antagonize iontophoretically applied GABA, was found to reduce the inhibition of test responses evoked by conditioning stimuli in almost all of the neurons studied. In most cases, no excitatory responses to conditioning stimuli directed outside the original excitatory receptive field were revealed by application of the GABA antag...Continue Reading

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Citations

Apr 1, 2003·Thalamus & Related Systems·M NeubigT J Sejnowski
Jan 1, 1991·The European Journal of Neuroscience·T. E. Salt, S. A. Eaton
Oct 20, 2009·Neurobiology of Disease·Anna P AndreouPeter J Goadsby
Jun 13, 2008·The European Journal of Neuroscience·Rajen B MistryJohn W Crabtree
Jan 9, 2013·The European Journal of Neuroscience·John W CrabtreeJohn T R Isaac
Jan 1, 1993·Somatosensory & Motor Research·D D RasmussonS A Northgrave
Nov 9, 2018·Frontiers in Systems Neuroscience·John W Crabtree

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