Evidence supporting the hypothesis that GABA-ergic mechanisms are involved in controlling mammalian cardiovascular function has been reviewed and analyzed. In vivo and in vitro studies with GABA-agonists and GABA-antagonists have revealed that activation of GABA-receptors is involved in the control of blood pressure and heart rate. Further studies conducted with agents that modify central and/or peripheral GABA-ergic systems could lead to the discovery of drugs that might be useful for treating certain cardiovascular disorders in man, such as hypertension and stroke, and should increase our understanding of the pathophysiological bases of such disorders.
Muscimol and related GABA receptor agonists: the potency of GABAergic drugs in vivo determined after intranigral injection
Pharmacological characterization of GABA receptors mediating vasodilation of verebral arteries in vitro
GABA receptor control of parasympathetic outflow to heart: characterization and brainstem localization
Central antihypertensive properties of muscimol and related gamma-aminobutyric acid agonists and the interaction of muscimol with baroreceptor reflexes
Effects of central GABA receptor agonism and antagonism on evoked diencephalic cardiovascular responses
Reductions in blood pressure, heart rate and renal sympathetic nerve discharge in cats after the central administration of muscimol, a GABA agonist
Neuroanatomy of central cardiovascular control. Nucleus tractus solitarii: afferent and efferent neuronal connections in relation to the baroreceptor reflex arc
Inhibition of centrally-evoked pressor responses by diazepam: evidence for an exclusively supramedullary action
Indirect effects of amino-acids on sympathetic ganglion cells mediated through the release of gamma-aminobutyric acid from glial cells
Depressor effects of isoguvacine propyl ester and isoarecaidine propyl ester due to stimulation of central GABA receptors in the cat
gamma-Aminobutyric acid and postganglionic sympathetic transmission in the pulmonary artery of the rabbit
Evidence for a neuromodulatory role of GABA at the first synapse of the baroreceptor reflex pathway. Effects of GABA derivatives injected into the NTS
Two actions of gamma-aminobutyric acid on the responses of the isolated basilar artery from the rabbit
Evidence for the presence of a tonically active forebrain GABA system influencing central sympathetic outflow in the cat
Inhibition of baroreflex following microinjection of GABA or morphine into the nucleus tractus solitarii in rabbits
Research into the functional components and antioxidant activities of North China rice wine (Ji Mo Lao Jiu)
Characterization and comparative genomic analysis of gamma-aminobutyric acid (GABA)-producing lactic acid bacteria from Thai fermented foods.
Identification of a New Giant Emrbryo Allele, and Integrated Transcriptomics and Metabolomics Analysis of Giant Embryo Development in Rice.
Cardiovascular Disease Pathophysiology
Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.