PMID: 9178375Apr 1, 1997Paper

gamma-Aminobutyric acid contributes to modulation of cardiorespiratory control after chronic ventilatory loading

Respiration Physiology
R S RaoS M Scharf

Abstract

Diseases imposing chronic ventilatory loads may depress ventilation and cause chronic hypercapnia. This may be a result of mechanical loading imposed on pre-existing decreased respiratory drive or functional alteration of neural circuits involved in ventilatory control. To evaluate these possibilities, chronic resistive airway loading was imposed in rats via a circumferential tracheal band which tripled tracheal resistance (obstructed group). Sham surgery was performed in controls. After 8 weeks, animals were anesthetized (urethane) and tracheostomy performed relieving increased tracheal resistance. The ventral medullary surface (VMS) was exposed and the intermediate area (IA) identified. The integrated diaphragm EMG (EMGDI) was recorded. The obstructed group was hypercapnic while controls were eucapnic (PCO2, 45.1 +/- 7.9 vs. 37.6 +/- 3.4 Torr; P < 0.001). Respiratory rate (RR) remained lower in obstructed than in control animals despite relief of the resistive load by tracheostomy (58.5 +/- 5.1 vs. 75.4 +/- 5.4 bpm; P < 0.05). Application of 1 mM bicuculline soaked pledgets (BIC) to the IA of the VMS significantly increased EMGDI in obstructed but not in control animals (27.5 +/- 5.5 vs. 5.2 +/- 4.4%; P < 0.006). RR was unaff...Continue Reading

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Citations

Dec 25, 2009·Neuroscience and Behavioral Physiology·N P AleksandrovaT G Ivanova
Jan 14, 1999·Journal of Applied Physiology·H E GreenbergS M Scharf
Apr 12, 2001·Journal of Applied Physiology·S D LeeG A Farkas

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