Gamma-aminobutyric acid edited echo-planar spectroscopic imaging (EPSI) with MEGA-sLASER at 7T

Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
Peter O MagnussonEsben T Petersen

Abstract

For rapid spatial mapping of gamma-aminobutyric acid (GABA) at the increased sensitivity and spectral separation for ultra-high magnetic field strength (7 tesla [T]), an accelerated edited magnetic resonance spectroscopic imaging technique was developed and optimized for the human brain at 7 T. A MEGA-sLASER sequence was used for GABA editing and volume selection to maximize editing efficiency and minimize chemical shift displacement errors. To accommodate the high bandwidth requirements at 7 T, a single-shot echo planar readout was used for rapid simultaneous encoding of the temporal dimension and 1 spatial. B0 and B1 field aspects specific for 7 T were studied together with correction procedures, and feasibility of the EPSI MEGA-sLASER technique was tested in vivo in 5 healthy subjects. Localized edited spectra could be measured in all subjects giving spatial GABA signal distributions over a central brain region, having 45- to 50-Hz spatial intervoxel B0 field variations and up to 30% B1 field deviations. MEGA editing was found unaffected by the B0 inhomogeneities for the optimized sequence. The correction procedures reduced effects of intervoxel B0 inhomogeneities, corrected for spatial editing efficiency variations, and com...Continue Reading

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Citations

May 1, 2020·NMR in Biomedicine·Andrew A MaudsleyBrian J Soher
May 14, 2020·NMR in Biomedicine·Wolfgang BognerAnke Henning
Dec 20, 2019·Investigative Radiology·Lukas HingerlWolfgang Bogner
Sep 19, 2020·NMR in Biomedicine·In-Young ChoiRobin A de Graaf

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Software Mentioned

VESPA
Matlab
MEGA

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