PMID: 8952001Nov 14, 1996Paper

Gamma-aminobutyric acid mediation of the inhibitory effect of nitric oxide on the arginine vasopressin and oxytocin responses to insulin-induced hypoglycemia

Regulatory Peptides
P ChioderaV Coiro

Abstract

Previous studies have demonstrated that the nitric oxide (NO) synthase inhibitor L-NAME exerts positive effects on the arginine vasopressin (AVP) and oxytocin (OT) responses to insulin-induced hypoglycemia, suggesting inhibitory actions of NO. The present study was designed to determine whether a gamma-aminobutyric acid (GABA)ergic pathway is involved in regulation of NO action. AVP and OT secretory patterns during insulin (0.15 IU/kg, i.v.)-tolerance tests (ITT) were examined in seven normal male subjects with (experimental tests) and without (control test) concomitant treatment with L-NAME (40 micrograms/kg injected plus 50 micrograms/kg infused, i.v.), the GABAergic agent sodium valproate (600 mg in three divided doses orally) or the combination of L-NAME and sodium valproate. Insulin-induced hypoglycemia increased by 2-fold (peak vs. baseline) plasma AVP and OT levels. In the presence of L-NAME, plasma AVP and OT levels rose 3-fold in response to hypoglycemia and were significantly higher than those in the control test. Administration of sodium valproate alone changed neither AVP nor OT secretory patterns during ITT. In contrast, sodium valproate abolished the facilitating effect of L-NAME on both AVP and OT responses to hy...Continue Reading

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Citations

Dec 3, 2005·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Tomás González-HernándezMaría del Carmen González
Jan 26, 2002·Microscopy Research and Technique·Takashi Higuchi, Chuma O Okere
Feb 5, 2005·American Journal of Physiology. Gastrointestinal and Liver Physiology·Diana GentilcoreKaren L Jones
Jan 13, 2004·Physiological Reviews·José Antunes-RodriguesSamuel M McCann
Nov 22, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Kaushik P Patel, Hong Zheng
Mar 15, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Kun ZhangKaushik P Patel

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