PMID: 9548552Apr 21, 1998Paper

Gamma-aminobutyric acidA receptors on a bistratified amacrine cell type in the rabbit retina

The Journal of Comparative Neurology
C L Zucker, B Ehinger

Abstract

Gamma-Aminobutyric acid (GABA) is considered to be a major inhibitory neurotransmitter in the inner plexiform layer of the retinas of all vertebrate species. It is contained in and released from nearly 40% of the amacrine cells and is known to play a major role in many aspects of visual processing. By using well-characterized antibodies to several subunits of the GABA(A) receptor, we have analyzed their localization on the cell bodies and dendritic trees of two amacrine cell populations in the rabbit retina, which have been either filled intracellularly with Lucifer yellow or stained immunohistochemically. Both populations are selectively stained by intravitreal injection of the fluorescent nuclear dye 4',6-diaminidin-2-phenylindoldihydrochloride (DAPI). We have found that the most significant concentration of the alpha1 and beta2/3 GABA(A) receptor subunits is localized to the DAPI-3 type amacrine cell. The perikarya of the DAPI-3 cells are found in the proximal inner nuclear layer and send their processes into two sublayers in sublaminae a and b of the inner plexiform layer. These processes abut but do not directly overlap those of the two mirror-symmetric populations of starburst amacrine cells. Because the cell bodies of th...Continue Reading

Citations

Aug 24, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Chih-Tien WangMarla B Feller
Feb 7, 2015·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·E Popova
Oct 25, 2006·Journal of Biomedical Science·Wen Shen, Zheng Jiang
Dec 26, 2006·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Nina A DmitrievaKent T Keyser
Jan 2, 2003·The Journal of Comparative Neurology·Nina A DmitrievaKent T Keyser
Nov 2, 2005·The Journal of Comparative Neurology·Charles L ZuckerNorberto M Grzywacz
Oct 10, 2014·Journal of Neurophysiology·Christianne E StrangKent T Keyser

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