Gamma-band activity in human posterior parietal cortex encodes the motor goal during delayed prosaccades and antisaccades.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
J Van Der WerfW P Medendorp

Abstract

Although it is well established that parietal cortex is important in processing sensorimotor transformations, less is known about the neuronal dynamics of this process in humans. Using magnetoencephalography, we investigated the dynamics of parietal oscillatory activity during saccade planning in terms of sensory and motor goal processing. In the experiments, a peripheral stimulus was flashed in either the left or right hemifield, followed by a 1.5 s delay period, after which the subject executed a saccade toward (prosaccade) or away from (antisaccade) the stimulus. In response to stimulus presentation, we observed an initial increase in gamma-band power (40-120 Hz) in a region in the posterior parietal cortex contralateral to the direction of the stimulus. This lateralized power enhancement, which was sustained in a more narrow frequency band (85-105 Hz) during the delay period of prosaccades, mapped to the hemisphere contralateral to the direction of the saccade goal during the delay period of antisaccades. These results suggest that neuronal gamma-band synchronization in parietal cortex represents the planned direction of the saccade, not the memorized stimulus location. In the lower-frequency bands, we observed sustained co...Continue Reading

Citations

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