PMID: 16522932Mar 9, 2006Paper

Gamma-cyclodextrin lowers postprandial glycemia and insulinemia without carbohydrate malabsorption in healthy adults

Journal of the American College of Nutrition
Michelle L AspBryan W Wolf

Abstract

Preliminary in vitro and animal studies have shown that gamma-cyclodextrin (GCD) is a slowly and completely digestible carbohydrate. The objective of this study was to determine the glycemic and insulinemic responses to GCD in humans. Breath hydrogen excretion was measured simultaneously to evaluate carbohydrate malabsorption. Healthy adult subjects (N = 32) received 50 g of carbohydrate from GCD or a rapidly digested maltodextrin (MD) in a double-masked, randomized, crossover design. Plasma glucose (fingerstick) and serum insulin (venous) concentrations were measured at baseline and at 15, 30, 45, 60, 90, 120, 150, and 180 min postprandially. Breath hydrogen excretion was monitored hourly for 8 h postprandially. The severity of gastrointestinal symptoms (nausea, cramping, distension, flatulence) was rated by the subjects on a ranked scale for two 24-h periods postprandially. The mean baseline-adjusted peak plasma glucose concentration was 47% lower (P < 0.001), and the mean baseline-adjusted peak serum insulin concentration was decreased by 45% (P < 0.001) after subjects consumed GCD compared with MD. Positive incremental area under the curve (0-120 min) was reduced 45% for plasma glucose and 49% for serum insulin by GCD compa...Continue Reading

References

Jun 1, 1992·Diabetic Medicine : a Journal of the British Diabetic Association·T M WoleverR G Josse
Nov 1, 1991·The American Journal of Clinical Nutrition·T M WoleverR G Josse
Apr 1, 1993·The Journal of Nutrition·B FlouriéJ C Rambaud
Feb 1, 1997·Diabetes Research and Clinical Practice·F R KaufmanN D Kaufman
Dec 8, 1998·International Journal of Sport Nutrition·L M BurkeM Hargreaves
Feb 3, 2000·Food Additives and Contaminants·G A KoutsouA Bär
May 4, 2002·JAMA : the Journal of the American Medical Association·David S Ludwig
Jun 26, 2002·The American Journal of Clinical Nutrition·Kaye Foster-PowellJanette C Brand-Miller
Sep 11, 2002·The Journal of Nutrition·Patricia M HeacockBryan W Wolf
Apr 4, 2003·The Journal of Nutrition·Bryan W WolfKevin C Maki

❮ Previous
Next ❯

Citations

Aug 5, 2009·Regulatory Toxicology and Pharmacology : RTP·Sharon S H ChoiTakashi Kuriki
Mar 13, 2015·Critical Reviews in Food Science and Nutrition·É FenyvesiL Szente
Feb 14, 2009·The Journal of International Medical Research·J L SlavinG Fotopoulos
Apr 4, 2021·Biomolecules·Svenja WüpperGerald Rimbach

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
D W Petersen, M R Osheroff
Regulatory Toxicology and Pharmacology : RTP
Zofia S Olempska-BeerMichael J DiNovi
© 2021 Meta ULC. All rights reserved