PMID: 3763397Sep 11, 1986Paper

Gamma delta beta-thalassaemias 1 and 2 are the result of a 100 kbp deletion in the human beta-globin cluster

Nucleic Acids Research
R TaramelliF G Grosveld

Abstract

The DNA spanning two large deletions in the human beta-globin gene cluster (gamma beta-thalassaemia 1 and 2) has been cloned by cosmid cloning and chromosomal walking. The entire region was mapped and analyzed for the presence of repetitive sequences. The results show that the affected loci have lost almost 100 kb of DNA in a deletion event not involving homologous or repetitive sequences.

References

Jan 1, 1979·Cytogenetics and Cell Genetics·A HagemeijerD Bootsma
Nov 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·L DiGiovanniW R Jelinek
Jul 1, 1980·Scientific American·W R BauerJ H White
Nov 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·S E AntonarakisD A Meyers
Aug 11, 1980·Nucleic Acids Research·L W CogginsJ Paul

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Citations

Jan 1, 1989·Somatic Cell and Molecular Genetics·P Dewyse, W E Bradley
Nov 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·E EpnerM Groudine
Sep 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·P T CurtinY W Kan
Oct 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·M C DriscollB P Alter
Nov 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·G JiménezT Enver
Feb 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·C H LowreyA W Nienhuis
Dec 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·J Y ChanY W Kan
Apr 11, 1991·Nucleic Acids Research·S PruzinaS Philipsen
Nov 11, 1992·Nucleic Acids Research·G JiménezT Enver
Sep 26, 2000·Molecular and Cellular Biology·W ZhouS M Jane
Jun 1, 1991·The Journal of Clinical Investigation·A E KulozikE Kleihauer
Nov 1, 1988·The American Journal of the Medical Sciences·M H Steinberg
Jan 1, 1990·Annals of the New York Academy of Sciences·F GrosveldP Fraser
Jun 9, 2012·Blood Cells, Molecules & Diseases·Helen RooksSwee Lay Thein
Sep 27, 2003·British Journal of Haematology·Laurence GameSwee Lay Thein
Mar 1, 1993·Baillière's Clinical Haematology·F GrosveldD Higgs
Apr 16, 2004·The Journal of Biological Chemistry·Wenlai ZhouStephen M Jane
Dec 1, 1988·American Journal of Medical Genetics·F Giannelli
Jun 29, 2000·Baillière's Clinical Haematology·S L Thein
Mar 1, 1993·Baillière's Clinical Haematology·S L Thein
Aug 25, 1989·Science·J NathansF Zwas

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