Gamma-delta T cells in BAL fluid of chronic lower respiratory tract infection

Chest
T FujiiS Kohno

Abstract

Gamma-delta (gamma/delta) T cells are thought to represent the first line of defense against various pathogenic microorganisms. The aim of the present study was to investigate whether gamma/delta T cells were increased in BAL fluid (BALF) of patients with diffuse panbronchiolitis (DPB), a model of chronic lower respiratory tract infection. The study population consisted of four groups, including patients with DPB, sarcoidosis, idiopathic pulmonary fibrosis, and normal subjects. Two-color direct immunofluorescence and flow cytometry were used for analysis of peripheral blood or BALF from these patients. The percentage of peripheral blood or BALF gamma/delta T cells relative to the total number of lymphocytes was similar in the four groups. Although the absolute number of gamma/delta T cells in BALF was significantly higher in DPB patients compared with the other three groups, the total lymphocyte number in BALF in DPB patients was increased and the number of BALF gamma/delta T cells correlated with the total lymphocyte number in BALF. Furthermore, the percentage and number of BALF gamma/delta T cells were not related to a certain group of pathogenic organisms or the number of colony-forming units. Our results suggest that gamma/...Continue Reading

References

Aug 1, 1992·The American Review of Respiratory Disease·A SatoH Hayakawa
Jan 1, 1992·The Journal of Experimental Medicine·K HiromatsuK Nomoto
Sep 1, 1991·The Journal of Experimental Medicine·K UyemuraR L Modlin
Jul 10, 1986·Nature·M B BrennerM S Krangel
Apr 1, 1994·American Journal of Respiratory and Critical Care Medicine·K NakataM Aoki

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Citations

Feb 26, 2000·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R Pawankar
Apr 14, 2021·Thorax·Anno SarisUNKNOWN ArtDECO consortium and the Amsterdam UMC COVID study group

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