Gamma-delta T-cells in patients with squamous cell carcinoma of the head and neck

Oral Oncology
Murat BasThomas K Hoffmann

Abstract

In our attempt to characterize a general immune-suppression found in patients with squamous cell carcinoma of the head and neck (SCCHN) we now focused on a subset of CD3 lymphocytes described as gamma/delta-T-cells, a cell type with potential relevance in non-MHC restricted anti-tumor immune responses. Peripheral blood of 33 SCCHN patients and 33 age-matched controls (CON) was evaluated for the frequency of gamma/delta-T-cells among CD3+ T-cells and their onset of apoptosis (Annexin V binding) by multicolor flow cytometry. Results were correlated with clinical parameters. Patients with SCCHN had a significantly higher proportion of gamma/delta-T-cells compared to healthy controls (4.4+/-0.4% for SCCHN vs. 3.0+/-0.3% for CON, p=0.01). However, this increase was not paralleled with a difference in the onset of apoptosis if compared to CON. There was also no correlation between the proportion of gamma/delta-T-cells and tumor stage. However, a significantly higher proportion of gamma/delta-T-cells was found in patients with recurrent or metachronous second primary SCCHN (6.0+/-1.0%) if compared to the other SCCHN (3.8+/-0.4%, p=0.02). In a follow up 3-6 months post-treatment patients showed a decrease of gamma/delta-T-cells among C...Continue Reading

References

Sep 1, 1993·The Journal of Experimental Medicine·M J Skeen, H K Ziegler
Feb 27, 1999·International Journal of Cancer. Journal International Du Cancer·A D LaadS V Chiplunkar
Jun 22, 2000·International Archives of Allergy and Immunology·D KabelitzD Wesch
Jun 14, 2001·Lancet·J Parkin, B Cohen
Apr 20, 2004·Cancer Immunology, Immunotherapy : CII·Thomas K HoffmannTheresa L Whiteside
Jun 3, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Iris KussTheresa L Whiteside

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Citations

Mar 29, 2008·Advances in Therapy·Oguz BilgiMustafa Yaylaci
Jan 22, 2011·Clinical & Developmental Immunology·Serena MeravigliaAngelo Martino
Jul 3, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Alan A Z AlexanderAndrei I Chapoval
Oct 16, 2013·Clinical Reviews in Allergy & Immunology·Ilan Bank, Victoria Marcu-Malina
Feb 6, 2007·Oral Oncology·Crispian Scully, Jose V Bagan
Jun 21, 2012·Clinica Chimica Acta; International Journal of Clinical Chemistry·A-Jin LeeIm-Hee Shin
Feb 25, 2020·Journal of Dental Research·A H HovavI Prinz
Jan 26, 2011·Histopathology·Laurence de Leval, Philippe Gaulard
Jan 29, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jian YeGuangyong Peng
May 5, 2018·Frontiers in Immunology·Timm HoeresMartin Wilhelm
Oct 5, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Chunling MaGuangyong Peng

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