PMID: 8580624Nov 1, 1995Paper

Gamma delta T lymphocytes in mumps meningitis patients

Acta Paediatrica
A BertottoR Vaccaro

Abstract

Flowcytometric analysis on T-cell subpopulations in the blood and cerebrospinal fluid (CSF) of 10 children with mumps meningitis (MM) revealed that the proportion of lymphocytes which bore the gamma delta T-cell receptor for antigen was significantly higher in CSF than in autologous and heterologous blood samples. gamma delta T-cell values in CSF of MM patients were also significantly higher than those calculated in CSF specimens from nine children with non-inflammatory neurological disorders. Whether and how the expanded CSF gamma delta T-lymphocyte subset, either CD8+ or double-negative (CD4-/CD8-), contributes to the eradication of mumps virus infection from the central nervous system represents a central focus of our ongoing research.

References

May 1, 1991·Journal of Neuroimmunology·J CorrealeH Link
May 1, 1990·The Journal of Experimental Medicine·C M ParkerM B Brenner
Nov 1, 1983·Archives of Disease in Childhood·H NagaiS Suzuki
Feb 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·R ShimonkevitzB L Kotzin
May 1, 1993·European Journal of Immunology·A BertottoR Vaccaro
May 14, 1993·Science·A Lanzavecchia

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