Gamma glutamyl transferase

Critical Reviews in Clinical Laboratory Sciences
John B Whitfield

Abstract

Serum gamma-glutamyl transferase (GGT) has been widely used as an index of liver dysfunction and marker of alcohol intake. The last few years have seen improvements in these areas and advances in understanding of its physiological role in counteracting oxidative stress by breaking down extracellular glutathione and making its component amino acids available to the cells. Conditions that increase serum GGT, such as obstructive liver disease, high alcohol consumption, and use of enzyme-inducing drugs, lead to increased free radical production and the threat of glutathione depletion. However, the products of the GGT reaction may themselves lead to increased free radical production, particularly in the presence of iron. There have also been important advances in the definition of the associations between serum GGT and risk of coronary heart disease, Type 2 diabetes, and stroke. People with high serum GGT have higher mortality, partly because of the association between GGT and other risk factors and partly because GGT is an independent predictor of risk. This review aims to summarize the knowledge about GGT's clinical applications, to present information on its physiological roles, consider the results of epidemiological studies, an...Continue Reading

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Mar 13, 2018·Canadian Journal of Physiology and Pharmacology·Houda BouhajjaNoura Bougacha-Elleuch
Aug 24, 2013·Journal of Pediatric Gastroenterology and Nutrition·Ibrahim M HirfanogluYildiz Atalay
Jan 27, 2018·Journal of Enzyme Inhibition and Medicinal Chemistry·Constantin BălăeţGabi Valeriu Dincă
Jan 8, 2019·Critical Reviews in Food Science and Nutrition·Muhammad SaeedSun Chao
Apr 25, 2006·American Journal of Human Biology : the Official Journal of the Human Biology Council·Phillip E MeltonM H Crawford
Dec 20, 2018·Liver International : Official Journal of the International Association for the Study of the Liver·Keiichi YuwakiJPHC Study Group
Sep 27, 2007·Circulation Journal : Official Journal of the Japanese Circulation Society·Anoop Shankar, Jialiang Li
Feb 9, 2019·Journal of Stroke·Evgeny SidorovJairam K P Vanamala
Mar 22, 2008·Human Genetics·Nora HeisterkampTam P Sneddon
Mar 20, 2008·Phytotherapy Research : PTR·Sang Il LeeYong Chool Boo
Jan 27, 2018·Annals of Neurology·Wookjin YangSeung-Hoon Lee
Jul 25, 2008·Amino Acids·T VermeulenJ Häberle
Feb 7, 2019·Expert Review of Molecular Diagnostics·Yakup Bozkaya, Ozan Yazıcı
Dec 17, 2009·The American Journal of Gastroenterology·Chien-Yu LinPau-Chung Chen
Mar 2, 2006·Critical Reviews in Food Science and Nutrition·Jane V Higdon, Balz Frei
Dec 18, 2012·International Urology and Nephrology·Mahmut Ilker YilmazJuan Jesus Carrero
Nov 29, 2012·Coronary Artery Disease·Giampaolo NiccoliFilippo Crea
Jun 21, 2019·Antioxidants & Redox Signaling·Wusheng Xiao, Joseph Loscalzo
Jul 25, 2014·Journal of Strength and Conditioning Research·Tomasz ChameraPaweł Cięszczyk
Jul 28, 2016·Canadian Journal of Physiology and Pharmacology·Kadry SadekReham Abouelkhair
Jul 2, 2016·American Journal of Physiology. Gastrointestinal and Liver Physiology·Kaneto TamuraMikihiro Tsutsumi
Dec 11, 2019·Genetic Testing and Molecular Biomarkers·Cun-Fei LiuYan-Jin Wei
Jan 17, 2004·Clinical Chemistry·Duk-Hee LeeCardiovascular Risk Development in Young Adults Study
Mar 27, 2007·Clinical Chemistry·Lili Kazemi-ShiraziClaudia Marsik
Jan 5, 2007·Clinical Chemistry·John B Whitfield
Dec 2, 2019·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Shea J AndrewsKaarin J Anstey
Jul 20, 2006·Journal of Medical Microbiology·Henrik AnderssonAnders Sjöstedt
Aug 3, 2017·Diabetologia·Sara L WhiteUPBEAT Consortium
Jun 7, 2019·BMC Veterinary Research·María Dolores Contreras-AguilarJose Joaquín Cerón
May 17, 2011·The Journal of the Acoustical Society of America·Ratan K Saha, Michael C Kolios
Aug 2, 2016·Journal of Clinical Gastroenterology·Suzanne E MahadyJacob George
Feb 13, 2013·Coronary Artery Disease·Ozgür ÇiftçiHaldun Müderrisoğlu
Jan 10, 2020·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Rianne van LieshoutSandra Beijer
Jul 25, 2020·Journal of Viral Hepatitis·Anika WrankeCihan Yurdaydin
Sep 5, 2013·Biological Chemistry·Francisco J Sánchez-GómezSantiago Lamas
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Mar 11, 2017·Clinical Chemistry and Laboratory Medicine : CCLM·You-Fan PengGuo-Gang Pan
Sep 23, 2011·The Journal of Pharmacology and Experimental Therapeutics·Shinya YamamotoYasuo Matsumura