gamma-Glutamyl transpeptidase activity in liver disease: serum elevation is independent of hepatic GGTP activity

Clinica Chimica Acta; International Journal of Clinical Chemistry
M J SelingerM M Kaplan

Abstract

gamma-Glutamyl transpeptidase activity was measured in liver and serum from 110 patients undergoing diagnostic liver biopsy, including patients with alcoholic liver disease, fatty liver not due to alcohol, primary biliary cirrhosis, persistent hepatic disease, chronic active hepatitis and normal livers. Serum gamma-glutamyl transpeptidase was markedly elevated in patients with alcoholic liver disease and primary biliary cirrhosis while mean hepatic gamma-glutamyl transpeptidase activity was significantly increased only in the alcoholic liver disease group. There was considerable overlap of individual enzyme values among the different disease groups. There was no inhibitors or activators of liver gamma-glutamyl transpeptidase in any of these disorders. The increased liver activity was not related to the degree of hepatic fibrosis or cirrhosis. There was no correlation between hepatic and serum gamma-glutamyl transpeptidase activity. Hepatic and serum gamma activities were equally increased in individuals with alcoholic liver disease whether or not they were drinking at the time of the study. The data suggest that increased hepatic gamma-glutamyl transpeptidase activity is neither specific for alcoholic liver disease nor essentia...Continue Reading

References

Sep 1, 1978·Clinica Chimica Acta; International Journal of Clinical Chemistry·N E Huseby, T Vik
Apr 20, 1978·The New England Journal of Medicine·C S Lieber
Sep 1, 1972·Gut·J B WhitfieldD W Moss
Jun 1, 1972·Clinica Chimica Acta; International Journal of Clinical Chemistry·S B Rosalki, D Rau
Jun 1, 1972·Clinica Chimica Acta; International Journal of Clinical Chemistry·J G RollasonD Robinson
Mar 1, 1970·The Journal of Clinical Investigation·M M Kaplan, A Righetti
Nov 1, 1966·Clinica Chimica Acta; International Journal of Clinical Chemistry·A Szewczuk

Citations

Dec 1, 1988·Digestive Diseases and Sciences·J J Reichling, M M Kaplan
Sep 21, 2013·Biomarkers in Medicine·Ryan BradleyDavid R Jacobs
Jan 31, 2014·Indian Journal of Clinical Biochemistry : IJCB·Prasad P TorkadiA K Bhute
Jun 1, 1992·The American Journal of the Medical Sciences·A A Mihas, M Tavassoli
Aug 1, 1987·European Journal of Clinical Investigation·R TeschkeM Nishimura
Jan 1, 1986·Alcoholism, Clinical and Experimental Research·M Salaspuro
Jun 1, 1992·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·B JankáskováF Sťastný
Jan 1, 1985·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·F SťastnýB Hájková
Sep 21, 2001·Critical Reviews in Clinical Laboratory Sciences·J B Whitfield

Related Concepts

Chronic Disease
Steatohepatitis
Gamma-glutamyl transferase
Hepatitis
Liver
Biliary Cirrhosis, Secondary
Liver Dysfunction
Alcoholic Liver Diseases

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