Gamma-Glutamyltransferase and Risk of Acute Coronary Syndrome in Young Chinese Patients: A Case-Control Study

Disease Markers
Yuli HuangYunzhao Hu

Abstract

Serum gamma-glutamyltransferase (GGT) is a biomarker of hepatic disease. Recent studies have shown that GGT may also associate with the risk of coronary artery disease. However, the underlying mechanisms of this association are still unclear. This study included 216 young patients with acute coronary syndrome (aged ≤55years) and 227 age-matched controls with normal findings by coronary angiography or coronary computed tomography angiography. We use standard colorimetric techniques and sandwich enzyme-linked immunosorbent assay to measure the levels of GGT and oxidized low-density lipoprotein (ox-LDL), respectively. Traditional risk factors of coronary artery disease, including smoking, diabetes mellitus, hypertension, dyslipidemia, and obesity/overweight, were evaluated according to the current guidelines. The levels of GGT were significantly correlated with body mass index and levels of triglyceride, fasting plasma glucose, aspartate aminotransferase, and ox-LDL (all P < 0.05). Multivariate logistic regression analysis showed that GGT was significantly associated with the risk of acute coronary syndrome in young Chinese patients (OR = 1.53, 95% CI = 1.09-2.15) after adjusting for traditional risk factors, including sex, age, q...Continue Reading

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Citations

May 27, 2020·Oxidative Medicine and Cellular Longevity·Shaomin YangYuli Huang
Dec 6, 2020·International Journal of Environmental Research and Public Health·Aleksander DanikiewiczBarbara Zubelewicz-Szkodzinska
Jul 6, 2021·Frontiers in Cardiovascular Medicine·Shaomin YangHaixiong Chen

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Methods Mentioned

BETA
hormone replacement therapy
enzyme-linked immunosorbent assay
imaging techniques

Software Mentioned

SPSS Statistics

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