gamma-Glutamyltransferase in human and mouse breast tumours

Clinica Chimica Acta; International Journal of Clinical Chemistry
J DawsonT J Peters


A series of experimental mouse tumours were assayed for their gamma-glutamyltransferase activities. Significantly raised activities were found in a transplantable spontaneous mammary carcinoma compared to normal or lactating mouse breast. A study was therefore undertaken of human breast tumours. Carcinomas showed significantly elevated enzyme levels when compared with normal tissue or histologically uninvolved tissue from a breast containing a carcinoma. Fibroadenoma and chronic mastitis also showed significantly elevated levels when compared with normal tissue and did not differ significantly from carcinoma tissue. Benign breast cyst fluid showed very high levels of enzyme activity. Binding properties of the enzyme to Con A-Sepharose suggested that while normal tissue and fibroadenomas contained only asialated enzyme, carcinomas, chronic mastitis and cyst fluid contained a substantial proportion of sialated enzyme.


Sep 1, 1981·The Histochemical Journal·M Vanderlaan, W Phares
May 5, 1981·Clinica Chimica Acta; International Journal of Clinical Chemistry·T HadaY Yamamura
Dec 30, 1983·Clinica Chimica Acta; International Journal of Clinical Chemistry·N E Huseby, T J Eide
Aug 1, 1997·Breast Cancer Research and Treatment·J R DurhamM H Hanigan
Jul 1, 1983·Scandinavian Journal of Gastroenterology·H SchjønsbyD W Skagen
Jul 1, 1991·Journal of Dental Research·L Zhang, D Mock
Jun 7, 1982·FEBS Letters·J L DingT J Peters
Jun 3, 2010·British Journal of Cancer·I S Fentiman, D S Allen
Apr 26, 2012·British Journal of Cancer·I S Fentiman
Mar 22, 2020·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Danila CoradiniFederico Ambrogi
Jan 1, 1980·CRC Critical Reviews in Clinical Laboratory Sciences·D M Goldberg
Oct 19, 2013·Liver International : Official Journal of the International Association for the Study of the Liver·Tao LiJia Fan
May 18, 2018·Inflammopharmacology·Gilcy George Kallivalappil, Girija Kuttan


Jul 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·A NovogrodskyA Meister
Apr 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·S Jaken, M Mason
Mar 1, 1975·FEBS Letters·F BinkleyR W Powell
Apr 6, 1973·Science·A Meister
Aug 15, 1970·Experientia·S Fiala, A E Fiala
May 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·H B Bosmann, T C Hall
Oct 22, 1970·The New England Journal of Medicine
Oct 1, 1966·Analytical Biochemistry·J B Le Pecq, C Paoletti
Aug 1, 1964·Cancer·H H DAVISJ B DAVIS

Related Concepts

Clinical Enzyme Tests (Procedure)
Gamma-glutamyl transferase
Tumor Lysis Syndrome
Gamma Glutamyl Transferase Measurement
Enzyme Activity
Blood Enzyme Activity (Lab Test)

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Synapse Loss as Therapeutic Target in MS

As we age, the number of synapses present in the human brain starts to decline, but in neurodegenerative diseases this occurs at an accelerated rate. In MS, it has been shown that there is a reduction in synaptic density, which presents a potential target for treatment. Here is the latest research on synapse loss as a therapeutic target in MS.

Artificial Intelligence in Cardiac Imaging

Artificial intelligence (ai) techniques are increasingly applied to cardiovascular (cv) medicine in cardiac imaging analysis. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

Social Learning

Social learning involves learning new behaviors through observation, imitation and modeling. Follow this feed to stay up to date on the latest research.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Single Cell Chromatin Profiling

Techniques like ATAC-seq and CUT&Tag have the potential to allow single cell profiling of chromatin accessibility, histones, and TFs. This will provide novel insight into cellular heterogeneity and cell states. Discover the latest research on single cell chromatin profiling here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.

Related Papers

Clinica Chimica Acta; International Journal of Clinical Chemistry
T HadaY Yamamura
Clinica Chimica Acta; International Journal of Clinical Chemistry
N E Huseby, T J Eide
Clinica Chimica Acta; International Journal of Clinical Chemistry
T HadaT Sonoda
© 2020 Meta ULC. All rights reserved