PMID: 6144333Mar 1, 1984

Gamma-glutamyltranspeptidase induction by cortisol in liver parenchyma of unweaned rats

Bioscience Reports
R TongianiE Chieli


In contrast to many differentiated hepatic functions developing after birth, very little is known about in vivo glucocorticoid influences on postnatal expression of fetal liver enzymes, such as GGT. This study showed that cortisol markedly induces liver GGT activity in unweaned rats, but has no effect after weaning. Enzyme induction was dose- and time-dependent and occurred in parenchymal cells, progressing with time from zone 1 to zone 2 of the liver acinus. Zone-3 hepatocytes were unresponsive even after a 5-day treatment. Lag-times for GGT induction in zones 1 and 2 of the liver acinus were 1 to 2 days and 2 to 3 days, respectively. From this, a permissive cell change, determined by the hormone administration itself, seems required for the hepatocyte GGT induction by cortisol in pre-weaning rats.


Jan 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·A E SiricaH C Pitot
Dec 1, 1977·Molecular and Cellular Endocrinology·A Le Cam, P Freychet
Aug 1, 1969·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·A M RutenburgA M Seligman
May 1, 1980·Molecular and Cellular Endocrinology·M C BillonJ Hanoune
Jan 1, 1983·Molecular and Cellular Biochemistry·R BaroukiJ Hanoune
Jan 1, 1980·Advances in Cancer Research·E Farber, R Cameron

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Enzyme Induction
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