PMID: 2509611Nov 1, 1989Paper

Gamma interferon induces monocyte killing of Listeria monocytogenes by an oxygen-dependent pathway; alpha- or beta-interferons by oxygen-independent pathways

Journal of Leukocyte Biology
R Peck

Abstract

Human peripheral blood monocytes purified by counterflow centrifugal elutriation were treated with recombinant interferons-gamma (IFN-gamma), alpha (IFN-alpha), or beta (IFN-beta)--and tested for their capacity to kill Listeria monocytogenes. All three IFNs increased the monocyte bactericidal activity in a dose-dependent fashion. Exogeneous catalase, an inhibitor of monocyte-generated hydrogen peroxide, did not affect bactericidal activity. However, exogenous superoxide dismutase inhibited killing by IFN-gamma-activated monocytes, but not by IFN-alpha- or IFN-beta-activated monocytes. By contrast, exogenous soybean trypsin inhibitor inhibited killing by IFN-alpha or IFN-beta-activated monocytes, but not by IFN-gamma-activated monocytes. Combinations of IFN-gamma and IFN-alpha resulted in no increase in bactericidal activity. Finally, treatment with IFN-gamma resulted in different receptiveness of the cell to subsequent oxidative burst-stimulating signals than did treatment with either IFN-alpha or IFN-beta. These results suggest that monocytes treated with IFN-gamma kill L. monocytogenes by an oxygen-dependent mechanism, but treatment with IFN-alpha or IFN-beta elicits principally oxygen-independent mechanisms.

Citations

Jan 1, 1992·Free Radical Research Communications·A Haas, W Goebel
Feb 2, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mojca Skoberne, Gernot Geginat
Jul 1, 1995·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·B SerushagoR Bortolussi
May 6, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ann M DavisJ David Farrar
Aug 21, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jessica ChuJohn I Gallin
May 1, 1995·Clinical and Experimental Immunology·A RivierA M Campbell
Dec 15, 2005·Journal of Virology·Ashley L SteedHerbert W Virgin
Feb 26, 2003·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Katherine KedzierskaSuzanne M Crowe
Jul 1, 1991·The American Journal of the Medical Sciences·B A DubayboR W Carlson

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