Gamma irradiation-induced oxidative stress and developmental impairment in the hermaphroditic fish, Kryptolebias marmoratus embryo

Environmental Toxicology and Chemistry
Jae-Sung RheeJae-Seong Lee

Abstract

This study investigated the effects of gamma radiation on the early developmental stages in hermaphroditic fish embryos of Kryptolebias marmoratus. The authors measured reactive oxygen species (ROS) level and antioxidant enzyme activities with the endpoint hatching rate after gamma irradiation of different embryonic stages. Then, the transcriptional changes of antioxidant enzyme-coding genes were evaluated by quantitative real-time reverse transcription polymerase chain reaction in response to gamma radiation on embryonic stages. Gamma radiation inhibited hatching rate and caused developmental impairment in a dose-dependent manner. Embryos showed tolerances in a developmental stage-dependent manner, indicating that early embryonic stages were more sensitive to the negative effects of gamma radiation than were later stages. After 5 Gy rate of radiation, the ROS level increased significantly at embryonic stages 2, 3, and 4 with a significant induction of all antioxidant enzyme activities. The expressions of glutathione S-transferase isoforms, catalase, superoxide dismutase (Mn-SOD, Cu/Zn-SOD), glutathione reductase, and glutathione peroxidase mRNA were upregulated in a dose-and-developmental stage-dependent manner. This finding i...Continue Reading

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Citations

Oct 31, 2015·Aquatic Toxicology·B GagnaireC Adam-Guillermin
Nov 11, 2014·Environmental Science and Pollution Research International·Eun-Ji WonJae-Seong Lee
Apr 25, 2014·Marine Pollution Bulletin·Jae-Sung Rhee, Jae-Seong Lee
May 28, 2016·Bulletin of Environmental Contamination and Toxicology·Eun-Ji WonJae-Seong Lee
Sep 2, 2016·International Journal of Radiation Biology·Alaa El-Din Hamid SayedHiroshi Mitani
Nov 3, 2016·Radiation and Environmental Biophysics·Miao HuYongdong Wang
Apr 11, 2017·Ecotoxicology and Environmental Safety·M K Praveen KumarR C Chaubey
Mar 22, 2020·Environmental Research·Ritu Sharma, Rajinder Jindal
Mar 3, 2019·Ecotoxicology and Environmental Safety·B GagnaireL P Belzunces

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