Gamma-irradiation of lyophilised wound healing wafers

International Journal of Pharmaceutics
Kerr H MatthewsGillian M Eccleston

Abstract

Lyophilised wafers are being developed as drug delivery systems that can be applied directly to the surface of suppurating wounds. They are produced by the freeze-drying of polymer solutions and gels. This study investigates the possibility of sterilising these glassy, solid dosage forms with gamma-irradiation and determining the rheological properties of rehydrated wafers post-irradiation. One series of wafers was formulated using sodium alginate (SA) modified with increasing amounts of methylcellulose (MC), the other being composed of xanthan gum (XG) and MC. Batches were divided into three lots, two of which were exposed to 25 and 40 kGrays (kGy) of Cobalt-60 gamma-irradiation, respectively, the third being retained as a non-irradiated control. Apparent viscosities of solutions/gels resulting from the volumetric addition of distilled water to individual wafers were determined using continuous shear, flow-rheometry. Flow behaviour on proprietary suppurating surfaces was also determined. Large reductions in viscosity were apparent for irradiated SA samples while those of XG appeared to be largely unaffected. In addition, an increase in the yield stress of xanthan formulations was observed. Xanthan wafers appeared to withstand ...Continue Reading

Citations

Jun 25, 2013·International Journal of Pharmaceutics·Olga LabovitiadiKerr H Matthews
Jul 28, 2012·Therapeutic Delivery·Olga LabovitiadiKerr H Matthews
Apr 1, 2014·International Journal of Pharmaceutics·Galal M El-MahroukMaie S Taha
Apr 15, 2009·Drug Development and Industrial Pharmacy·Joshua S BoatengKerr H Matthews
Mar 12, 2015·Drug Development and Industrial Pharmacy·Shiow-Fern Ng, Hon-Lunn Leow
Oct 30, 2007·Journal of Pharmaceutical Sciences·Joshua S BoatengGillian M Eccleston
Apr 5, 2014·Journal of Pharmaceutical Sciences·Harshavardhan V PawarJohn Tetteh
Jan 20, 2010·International Journal of Pharmaceutics·Joshua S BoatengGillian M Eccleston
May 30, 2009·International Journal of Pharmaceutics·Joshua S BoatengGillian M Eccleston
May 31, 2012·International Journal of Pharmaceutics·Hnin-Ei ThuShiow-Fern Ng
Sep 24, 2013·International Journal of Pharmaceutics·Pramod C GadadRachel M Knott
Sep 4, 2013·Advanced Drug Delivery Reviews·Jenny K W LamIan C K Wong
Nov 23, 2013·Interventional Medicine & Applied Science·A Yekta OzerMeral Ozalp
Jun 18, 2014·Interventional Medicine & Applied Science·Gürhan Abuhanoğlu, A Yekta Ozer
Nov 23, 2013·Interventional Medicine & Applied Science·Selcan TurkerMustafa Korkmaz
Oct 27, 2020·Advanced Healthcare Materials·Amin ShavandiFerry Melchels

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