Gamma knife radiosurgery in patients with persistent acromegaly or Cushing's disease: long-term risk of hypopituitarism

Clinical Endocrinology
Or Cohen-InbarJason P Sheehan

Abstract

For patient with a recurrent or residual acromegaly or Cushing's disease (CD) after resection, gamma knife radiosurgery (GKRS) is often used. Hypopituitarism is the most common adverse effect after GKRS treatment. The paucity of studies with long-term follow-up has hampered understanding of the latent risks of hypopituitarism in patients with acromegaly or CD. We report the long-term risks of hypopituitarism for patients treated with GKRS for acromegaly or CD. From a prospectively created, IRB-approved database, we identified all patients with acromegaly or CD treated with GKRS at the University of Virginia from 1989 to 2008. Only patients with a minimum endocrine follow-up of 60 months were included. The median follow-up is 159·5 months (60·1-278). Thorough radiological and endocrine assessments were performed immediately before GKRS and at regular follow-up intervals. New onset of hypopituitarism was defined as pituitary hormone deficits after GKRS requiring corresponding hormone replacement. Sixty patients with either acromegaly or CD were included. Median tumour volume at time of GKRS was 1·3 cm(3) (0·3-13·4), and median margin dose was 25 Gy (6-30). GKRS-induced new pituitary deficiency occurred in 58·3% (n = 35) of patien...Continue Reading

References

Sep 15, 1988·Annals of Internal Medicine·T J MampalamC B Wilson
Jul 5, 2003·The Journal of Clinical Endocrinology and Metabolism·Roberto AttanasioMaura Arosio
Nov 6, 2004·Journal of Neuro-oncology·Edward R LawsRod Oskouian
May 19, 2005·The Journal of Clinical Endocrinology and Metabolism·Frédéric CastinettiThierry Brue
Mar 2, 2006·The Journal of Clinical Endocrinology and Metabolism·O M DekkersJ A Romijn
Nov 22, 2007·International Journal of Radiation Oncology, Biology, Physics·Bruce E PollockPaula J Schomberg
May 2, 2008·Skull Base : Official Journal of North American Skull Base Society ... [et Al.]·Gustavo Rassier IsolanOssama Al-Mefty
Dec 1, 2006·Journal of Neurosurgery·Mooseong KimYongtae Jung
Aug 7, 2008·The Journal of Clinical Endocrinology and Metabolism·O M DekkersJ A Romijn
Sep 2, 2008·Stereotactic and Functional Neurosurgery·Brent A TinnelSimon S Lo
Nov 5, 2008·Neurosurgery·Nasrin FatemiDaniel F Kelly
Mar 17, 2009·Journal of Experimental & Clinical Cancer Research : CR·Heng WanShubin Yuan
Jun 11, 2009·Clinical Endocrinology·Cristina L RonchiMaura Arosio
Jun 11, 2009·The Journal of Clinical Endocrinology and Metabolism·Frederic CastinettiThierry Brue
Feb 24, 2010·Nature Reviews. Endocrinology·Frederic CastinettiThierry Brue
Jun 15, 2010·Journal of Neurosurgery·Jason P SheehanMary Lee Vance
Jan 2, 2013·Neurosurgery·Zhiyuan XuJason P Sheehan
May 29, 2014·Neurosurgery·Cheng-Chia LeeJason P Sheehan

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Citations

May 27, 2017·Nature Reviews. Endocrinology·Paolo Beck-PeccozAndrea Lania
Feb 9, 2018·Journal of Neuro-oncology·Mohana Rao PatibandlaJason P Sheehan
Jul 27, 2018·Expert Opinion on Pharmacotherapy·Sylvère Störmann, Jochen Schopohl
Oct 6, 2018·Clinical Endocrinology·Hugh P Sims-WilliamsJohn Newell-Price
Feb 18, 2017·Pituitary·Monica Livia Gheorghiu
May 28, 2021·Pituitary·Hugh P Sims-WilliamsJohn Newell-Price

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