Gamma Knife surgery for patients with jugular foramen schwannomas: a multiinstitutional retrospective study in Japan

Journal of Neurosurgery
Toshinori HasegawaAkira Inoue

Abstract

OBJECTIVE This study aimed to explore the efficacy and safety of stereotactic radiosurgery in patients with jugular foramen schwannomas (JFSs). METHODS This study was a multiinstitutional retrospective analysis of 117 patients with JFSs who were treated with Gamma Knife surgery (GKS) at 18 medical centers of the Japan Leksell Gamma Knife Society. The median age of the patients was 53 years. Fifty-six patients underwent GKS as their initial treatment, while 61 patients had previously undergone resection. At the time of GKS, 46 patients (39%) had hoarseness, 45 (38%) had hearing disturbances, and 43 (36%) had swallowing disturbances. Eighty-five tumors (73%) were solid, and 32 (27%) had cystic components. The median tumor volume was 4.9 cm3, and the median prescription dose administered to the tumor margin was 12 Gy. Five patients were treated with fractionated GKS and maximum and marginal doses of 42 and 21 Gy, respectively, using a 3-fraction schedule. RESULTS The median follow-up period was 52 months. The last follow-up images showed partial remission in 62 patients (53%), stable tumors in 42 patients (36%), and tumor progression in 13 patients (11%). The actuarial 3- and 5-year progression-free survival (PFS) rates were 91% a...Continue Reading

References

May 1, 1984·Journal of Neurosurgery·A H KayeJ W Bay
Jun 1, 1995·Journal of Neurosurgery·M SamiiA Sepehrnia
Mar 17, 1999·International Journal of Radiation Oncology, Biology, Physics·S R MabantaF J Bova
Aug 14, 1999·Surgical Neurology·N MuthukumarJ C Flickinger
Apr 18, 2002·International Journal of Radiation Oncology, Biology, Physics·Bruce E PollockScott L Stafford
Aug 27, 2004·Neurosurgical Focus·Ricardo RaminaGuilherme Borges
Aug 27, 2004·Neurosurgical Focus·Bruce E Pollock
Jul 1, 2005·Neurosurgery·Ricardo RaminaMaurício Coelho Neto
Oct 19, 2006·Journal of Neurosurgery·Chul-Kee ParkHee-Won Jung
Oct 17, 2007·Journal of Neurosurgery·Toshinori HasegawaHiroshi Iizuka
Apr 24, 2009·International Journal of Radiation Oncology, Biology, Physics·Kentaro NishiokaHiroki Shirato
May 4, 2010·Skull Base : Official Journal of North American Skull Base Society ... [et Al.]·Masafumi FukudaYukihiko Fujii
Jul 14, 2010·Journal of Neurosurgery·Daniel D CavalcantiRobert F Spetzler
Jan 12, 2011·Neurosurgery·Matthew M KimballWilliam A Friedman
Jun 15, 2011·International Journal of Radiation Oncology, Biology, Physics·Christine CollenGuy Storme
Oct 4, 2011·Journal of Neurosurgery·Mohamed ElsharkawyJason P Sheehan
Dec 20, 2011·Journal of Neurosurgery·Robert M StarkeJason P Sheehan
Mar 8, 2012·Neurosurgical Review·Selçuk PekerM Necmettin Pamir
Jul 31, 2012·Journal of Neurosurgery·Song-Tao QiLu-Xiong Fang
Oct 26, 2012·Neurosurgery·Cara L SedneyTakanori Fukushima
Oct 8, 2013·Neurosurgery Clinics of North America·Toshinori Hasegawa
Oct 8, 2013·Neurosurgery Clinics of North America·Hideyuki Kano, L Dade Lunsford
Dec 2, 2014·Journal of Neurosurgery·Roman LiscakVilibald Vladyka

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