Gamma Knife surgery for patients with nonfunctioning pituitary macroadenomas: predictors of tumor control, neurological deficits, and hypopituitarism

Journal of Neurosurgery
Robert M StarkeJason P Sheehan

Abstract

Nonfunctioning pituitary macroadenomas often recur after microsurgery and thereby require further treatment. Gamma Knife surgery (GKS) has been used to treat recurrent adenomas. In this study, the authors evaluated outcomes following GKS of nonfunctioning pituitary macroadenomas and assessed predictors of tumor control, neurological deficits, and delayed hypopituitarism. Between June 1989 and March 2010, 140 consecutive patients with nonfunctioning pituitary macroadenomas were treated using GKS at the University of Virginia. The median patient age was 51 years (range 21-82 years), and 56% of patients were male. Mean tumor volume was 5.6 cm3 (range 0.6-35 cm3). Thirteen patients were treated with GKS as primary therapy, and 127 had undergone at least 1 open resection prior to GKS. Ninety-three patients had a history of hormone therapy prior to GKS. The mean maximal dose of GKS was 38.6 Gy (range 10-70 Gy), the mean marginal dose was 18 Gy (range 5-25 Gy), and the mean number of isocenters was 9.8 (range 1-26). Follow-up evaluations were performed in all 140 patients, ranging from 0.5 to 17 years (mean 5 years, median 4.2 years). Tumor volume remained stable or decreased in 113 (90%) of 125 patients with available follow-up imagi...Continue Reading

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Methods Mentioned

BETA
hormone replacement

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