Gamma Knife surgery for tumor-related trigeminal neuralgia: targeting both the tumor and the trigeminal root exit zone in a single session

Journal of Neurosurgery
Sung Kwon KimSun Ha Paek

Abstract

OBJECTIVE Gamma Knife surgery (GKS) represents an alternative treatment for patients with tumor-related trigeminal neuralgia (TRTN). However, in previous studies, the primary GKS target was limited to mass lesions. The authors evaluated whether GKS could target both the tumor and the trigeminal root exit zone (REZ) in a single session while providing durable pain relief and minimizing radiation dose-related complications for TRTN patients. METHODS The authors' institutional review board approved the retrospective analysis of data from 15 consecutive patients (6 men and 9 women, median age 67 years, range 45-79 years) with TRTN who had undergone GKS. In all cases, the radiation was delivered in a single session targeting both the tumor and trigeminal REZ. The authors assessed the clinical outcomes, including the extent of pain relief, durability of the treatment response, and complications. Radiation doses to organs at risk (OARs), including the brainstem and the cranial nerve VII-VIII complex, were analyzed as doses received by 2% or 50% of the tissue volume and the tissue volume covered by a dose of 12 Gy (V12Gy). RESULTS The median length of clinical follow-up was 38 months (range 12-78 months). Pain relief with GKS was initi...Continue Reading

References

Jun 1, 1986·Journal of Neurosurgery·E BullittJ Boyd
Sep 1, 1995·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·E M Monsell
Mar 17, 2000·Neurosurgery·B E PollockD A Gorman
Jun 23, 2000·International Journal of Radiation Oncology, Biology, Physics·C L RogersB L Speiser
Sep 22, 2001·Journal of Neurosurgery·K D FooteP S Kubilis
Jan 10, 2002·Journal of Neurosurgery·J RégisJ C Peragut
Aug 30, 2008·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·G CruccuUNKNOWN European Federation of Neurological Society
Jan 10, 2009·Journal of Neurosurgery·Chuan-Fu HuangLong-Yau Lin
Jun 12, 2009·International Journal of Radiation Oncology, Biology, Physics·Jung Ho HanSang Soon Jeong
Dec 3, 2010·Stereotactic and Functional Neurosurgery·Hideyuki KanoDouglas Kondziolka
Jan 3, 2012·International Journal of Radiation Oncology, Biology, Physics·Ehsan H BalagamwalaSamuel T Chao
Mar 3, 2012·World Neurosurgery·Shota TanakaMichael J Link
Apr 18, 2012·Stereotactic and Functional Neurosurgery·Sarah E SquireKevin P McMullen
Jan 2, 2014·Neurosurgical Focus·J Kevin DeMarco, John Huston

❮ Previous
Next ❯

Methods Mentioned

BETA
Gamma Knife surgery
sedation

Software Mentioned

SPSS
Gamma Plan

Related Concepts

Related Feeds

Auditory Perception

Auditory perception is the ability to receive and interpret information attained by the ears. Here is the latest research on factors and underlying mechanisms that influence auditory perception.