Gamma oscillations in somatosensory cortex recruit prefrontal and descending serotonergic pathways in aversion and nociception

Nature Communications
Linette Liqi TanRohini Kuner

Abstract

In humans, gamma-band oscillations in the primary somatosensory cortex (S1) correlate with subjective pain perception. However, functional contributions to pain and the nature of underlying circuits are unclear. Here we report that gamma oscillations, but not other rhythms, are specifically strengthened independently of any motor component in the S1 cortex of mice during nociception. Moreover, mice with inflammatory pain show elevated resting gamma and alpha activity and increased gamma power in response to sub-threshold stimuli, in association with behavioral nociceptive hypersensitivity. Inducing gamma oscillations via optogenetic activation of parvalbumin-expressing inhibitory interneurons in the S1 cortex enhances nociceptive sensitivity and induces aversive avoidance behavior. Activity mapping identified a network of prefrontal cortical and subcortical centers whilst morphological tracing and pharmacological studies demonstrate the requirement of descending serotonergic facilitatory pathways in these pain-related behaviors. This study thus describes a mechanistic framework for modulation of pain by specific activity patterns in the S1 cortex.

References

Sep 1, 1989·Journal of Neuroscience Methods·M Dragunow, R Faull
Oct 27, 1997·Journal of Neurophysiology·M KoltzenburgG R Lewin
Aug 24, 1999·The European Journal of Neuroscience·T HumbyL S Wilkinson
Jun 21, 2001·Proceedings of the National Academy of Sciences of the United States of America·J P JohansenB H Manning
Sep 18, 2002·Proceedings of the National Academy of Sciences of the United States of America·Marlene BartosPeter Jonas
Jan 13, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Markus BauerPascal Fries
Apr 26, 2007·PLoS Biology·Joachim GrossMarkus Ploner
Jul 24, 2007·NeuroImage·Luis Garcia-Larrea, Roland Peyron
Aug 31, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Michael HauckAndreas K Engel
Jun 6, 2008·Journal of Neurophysiology·G D IannettiA Mouraux
Jun 17, 2008·British Journal of Anaesthesia·I Tracey
Oct 28, 2008·Progress in Neurobiology·A Vania ApkarianPaul Y Geha
Dec 17, 2008·Journal of Neurophysiology·M N BalikiA V Apkarian
Apr 28, 2009·Nature·Jessica A CardinChristopher I Moore
Apr 28, 2009·Nature·Vikaas S SohalKarl Deisseroth
Sep 18, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Dajun XingRobert M Shapley
Sep 29, 2009·Nature Neuroscience·Tamara KingFrank Porreca
Nov 3, 2010·Progress in Neurobiology·Valéry LegrainAndré Mouraux
Nov 3, 2010·The Journal of Clinical Investigation·Petra Schweinhardt, M Catherine Bushnell
Mar 8, 2011·Cerebral Cortex·Enrico SchulzMarkus Ploner
Mar 25, 2011·Current Opinion in Neurobiology·Karim BenchenaneFrancesco P Battaglia
May 18, 2011·Computational Intelligence and Neuroscience·François TadelRichard M Leahy
Sep 2, 2011·Journal of Neurophysiology·Guangchen Ji, Volker Neugebauer
Oct 25, 2011·Neuron·Jeffry S Isaacson, Massimo Scanziani
Jun 1, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Z G ZhangG D Iannetti
Feb 12, 2013·Current Opinion in Neurobiology·Antonio CaputiHannah Monyer
Apr 12, 2013·The New England Journal of Medicine·Tor D WagerEthan Kross
Nov 10, 2013·Nature·Kenneth D Harris, Thomas D Mrsic-Flogel
Dec 10, 2013·Neuron·Eran StarkGyörgy Buzsáki
Apr 2, 2014·Journal of Visualized Experiments : JoVE·Christian NjooRohini Kuner
Feb 24, 2015·Nature Neuroscience·György Buzsáki, Erik W Schomburg
Mar 11, 2015·Cerebral Cortex·Enrico SchulzMarkus Ploner
Mar 17, 2015·Current Opinion in Neurobiology·Dominique L PritchettChristopher I Moore
Apr 13, 2015·Biological Psychiatry·Guillermo Gonzalez-BurgosDavid A Lewis
Jun 28, 2016·Pain·Brian W LeBlancCarl Y Saab

❮ Previous
Next ❯

Citations

Sep 14, 2019·Journal of Neural Transmission·Stevie Lockwood, Anthony H Dickenson
Jan 17, 2020·Journal of Neural Engineering·Xinling GuoZhe Sage Chen
Sep 29, 2020·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Junseok A Kim, Karen D Davis
Oct 4, 2019·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Johannes AchenbachMatthias Karst
Jun 12, 2020·Physiological Reviews·Rohini Kuner, Thomas Kuner
Feb 18, 2021·Journal of Computational Neuroscience·Yuru SongZhe S Chen
Mar 30, 2020·Current Biology : CB·Amrita SinghJing Wang
Mar 21, 2021·Neurophysiologie clinique = Clinical neurophysiology·Florian ChouchouLuis Garcia-Larrea
Apr 26, 2021·Neurophysiologie clinique = Clinical neurophysiology·Thibaut MussigmannAileen McGonigal
Jun 3, 2021·Biomedicines·Myeong Seong BakSun Kwang Kim
Apr 13, 2021·The Journal of Pain : Official Journal of the American Pain Society·Elisabeth S MayMarkus Ploner
Jun 16, 2021·Nature Reviews. Neuroscience·Linette Liqi Tan, Rohini Kuner
Jun 29, 2021·Trends in Neurosciences·Linette Liqi TanRohini Kuner
May 31, 2021·Current Opinion in Anaesthesiology·Sabine Himmelseher, Eberhard F Kochs
May 7, 2021·Journal of Neural Engineering·Lea TøttrupWinnie Jensen
Oct 4, 2020·Journal of Neuroscience Methods·Guanghao SunZhe Sage Chen
Oct 6, 2021·Journal of Neural Engineering·Zhe Sage Chen

❮ Previous
Next ❯

Software Mentioned

ANY
Leica Application Suite X
ABET II TOUCH
VersaDrive
Neuralynx
Cheetah
maze
Matlab
Brainstorm
ImageJ

Related Concepts

Related Feeds

Barrel cortex

Here is the latest research on barrel cortex, a region of somatosensory and motor corticies in the brain, which are used by animals that rely on whiskers for world exploration.

© 2022 Meta ULC. All rights reserved