Gamma Oscillations in the Basolateral Amygdala: Biophysical Mechanisms and Computational Consequences

ENeuro
Feng FengSatish S Nair

Abstract

The basolateral nucleus of the amygdala (BL) is thought to support numerous emotional behaviors through specific microcircuits. These are often thought to be comprised of feedforward networks of principal cells (PNs) and interneurons. Neither well-understood nor often considered are recurrent and feedback connections, which likely engender oscillatory dynamics within BL. Indeed, oscillations in the gamma frequency range (40 - 100 Hz) are known to occur in the BL, and yet their origin and effect on local circuits remains unknown. To address this, we constructed a biophysically and anatomically detailed model of the rat BL and its local field potential (LFP) based on the physiological and anatomical literature, along with in vivo and in vitro data we collected on the activities of neurons within the rat BL. Remarkably, the model produced intermittent gamma oscillations (∼50 - 70 Hz) whose properties matched those recorded in vivo, including their entrainment of spiking. BL gamma-band oscillations were generated by the intrinsic circuitry, depending upon reciprocal interactions between PNs and fast-spiking interneurons (FSIs), while connections within these cell types affected the rhythm's frequency. The model allowed us to conduc...Continue Reading

Citations

Dec 15, 2019·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Albert ParkSheena A Josselyn
May 23, 2019·Frontiers in Behavioral Neuroscience·Nathan S Ahlgrim, Joseph R Manns
Jul 19, 2019·Neuron·Drew B HeadleyDenis Paré

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Circular Statistics
NEURON
MATLAB

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