Abstract
While radiation has been the only well-established risk factor for salivary and thyroid cancers, the exact mechanisms remain unknown. We hypothesized that individuals with altered apoptotic response to gamma irradiation may be susceptible to salivary and thyroid cancers. We tested our hypothesis in a pilot case-control study of 29 patients with neoplasms of the salivary and thyroid glands and 29 cancer-free control subjects. Patients and control subjects were matched on age, sex, and ethnicity. In vitro gamma radiation-induced apoptosis in lymphocytes was quantified utilizing the TUNEL assay and flow cytometry. The mean apoptotic capacity was 13.55 +/- 10.54 for control subjects, 5.75 +/- 4.96 for patients with salivary gland carcinomas (p =.003), and 6.87 +/- 4.45 for patients with thyroid carcinomas (p =.006). These differences were associated with a 10-fold increased risk of salivary gland carcinoma (odds ratio [OR] = 10.71; 95% confidence interval [CI], 1.21-94.86) and a four-fold increased risk of thyroid carcinoma (OR = 3.93; 95% CI, 0.90-17.08). Our data suggests that gamma radiation-induced apoptosis may serve as a biomarker of genetic susceptibility to salivary and thyroid carcinoma, and further confirmatory studies wi...Continue Reading
References
Aug 1, 1972·British Journal of Cancer·J F KerrA R Currie
May 1, 1981·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·F Zampetti-Bosseler, D Scott
Nov 1, 1995·International Journal of Radiation Oncology, Biology, Physics·W C DeweyR E Meyn
Mar 10, 1995·Science·C B Thompson
Feb 1, 1994·International Journal of Radiation Biology·I R Radford, T K Murphy
Nov 2, 1994·Journal of the National Cancer Institute·M F LavinM Walsh
Dec 16, 1994·Science·L H Hartwell, M B Kastan
Mar 1, 1996·Endocrinology and Metabolism Clinics of North America·D Sarne, A B Schneider
Feb 13, 1997·Nature·C YinT Van Dyke
Jun 1, 1997·Journal of Pharmacological and Toxicological Methods·R T AllenD K Agrawal
Dec 24, 1997·Radiation and Environmental Biophysics·R MenzN E Crompton
Mar 25, 1998·Frontiers in Bioscience : a Journal and Virtual Library·M Story, R Kodym
Jul 17, 1998·The Laryngoscope·B ModanO Shpilberg
Dec 31, 1998·Virchows Archiv : an International Journal of Pathology·X HaoI C Talbot
Mar 5, 1999·Cellular and Molecular Life Sciences : CMLS·L D Attardi, T Jacks
Apr 27, 1999·Histopathology·D RaviM R Pillai
Dec 22, 1999·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·S AzmiN Singh
Feb 26, 2000·Carcinogenesis·J B Little
Oct 26, 2000·Nature·T RichA H Wyllie
Mar 6, 2002·Cancer·Homa Mirzaie-JonianiTorgny Stigbrand
Jun 7, 2002·Pathology, Research and Practice·T R PreethiM Radhakrishna Pillai
Feb 6, 2003·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael J Thun
Citations
Aug 17, 2006·Advances in Therapy·Bulent TurgutTaner Erselcan
Sep 27, 2006·Cancer Biotherapy & Radiopharmaceuticals·Bulent TurgutTaner Erselcan
Apr 6, 2006·European Journal of Nuclear Medicine and Molecular Imaging·Marina S KartachovaMarcel Verheij
Apr 17, 2012·Oral Oncology·Li XuErich M Sturgis
Mar 19, 2008·Current Problems in Surgery·Elizabeth G GrubbsDouglas B Evans
Jun 4, 2005·The Laryngoscope·Erich M SturgisQingyi Wei
Jul 28, 2007·Head & Neck·Tang HoErich M Sturgis
Aug 29, 2007·Cancer·Erich M Sturgis, Paul M Cinciripini
Jan 26, 2013·Cancer Letters·Tabish HussainRita Mulherkar