PMID: 11604478Oct 18, 2001Paper

Gamma-radiation sensitivity and risk of glioma

Journal of the National Cancer Institute
Melissa BondyQingyi Wei

Abstract

About 9% of human cancers are brain tumors, of which 90% are gliomas. gamma-Radiation has been identified as a risk factor for brain tumors. In a previous pilot study, we found that lymphocytes from patients with glioma were more sensitive to gamma-radiation than were lymphocytes from matched control subjects. In this larger case-control study, we compared the gamma-radiation sensitivity of lymphocytes from glioma patients with those from control subjects and investigated the association between mutagen sensitivity and the risk for developing glioma. We used a mutagen sensitivity assay (an indirect measure of DNA repair activity) to assess chromosomal damage. We gamma-irradiated (1.5 Gy) short-term lymphocyte cultures from 219 case patients with glioma and from 238 healthy control subjects frequency matched by age and sex. After irradiation, cells were cultured for 4 hours, and then Colcemid was added for 1 hour to arrest cells in mitosis. Fifty metaphases were randomly selected for each sample and scored for chromatid breaks. All statistical tests were two-sided. We observed a statistically significantly higher frequency of chromatid breaks per cell from case patients with glioma (mean = 0.55; 95% confidence interval [CI] = 0....Continue Reading

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Citations

Nov 22, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Weijie ZhuBainan Xu
Sep 16, 2003·Advances in Space Research : the Official Journal of the Committee on Space Research (COSPAR)·S M MortazaviA Niroomand-rad
Oct 8, 2003·International Journal of Radiation Oncology, Biology, Physics·Valentina d'AlesioMarco Salvatore
Mar 9, 2005·Thyroid : Official Journal of the American Thyroid Association·Ping XiongErich M Sturgis
Jul 9, 2010·Carcinogenesis·Yanhong LiuMelissa L Bondy
Oct 18, 2001·Journal of the National Cancer Institute·K J Dornfeld, T S Lawrence
Dec 22, 2005·Journal of the National Cancer Institute·Li-E WangQingyi Wei
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Jul 11, 2003·Health Physics·John D BoiceMarilyn Stovall
Jun 6, 2003·The Cancer Journal·Kenneth D AldapeMargaret Wrensch
Jan 7, 2009·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Yanhong LiuMelissa L Bondy
Apr 7, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Yanhong LiuMelissa Bondy
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