gamma-radiolysis study of the reduction by COO- free radicals of daunorubicin intercalated in DNA

Free Radical Biology & Medicine
A RouscillesC Ferradini

Abstract

The reduction of daunorubicin intercalated in DNA was studied using COO- free radicals produced by gamma-radiolysis as reductants. The reduction process of the drug intercalated in DNA was found to be very similar to the one of daunorubicin in aqueous solution without DNA. (a) the final product is the same (7-deoxy daunomycinone); (b) the reduction yield is the same [2.6 +/- 0.2) x 10(-7) mol.J-1); (c) H2O2 reacts with hydroquinone daunorubicin giving back the drug in a one-step reaction. However 7-deoxy daunomycinone precipitation was so slow that this aglycone could be reduced by COO- free radicals giving its hydroquinone form, which cannot be observed without DNA. This shows that the whole 4-electron reduction process takes place in DNA. The implications of these findings are discussed.

References

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Citations

Jan 1, 1991·Free Radical Biology & Medicine·C Houée-LevinC Ferradini
Sep 24, 2004·Prostaglandins, Leukotrienes, and Essential Fatty Acids·M M Sailaja Devi, Undurti Narasimha Das
Dec 7, 1993·Sykepleien. Fag·M Breimoen
Jan 1, 1990·Free Radical Research Communications·C Houée-LevinC Ferradini
Jan 1, 1990·Free Radical Research Communications·C Houée-LevinC Ferradini
Aug 18, 2021·International Journal of Radiation Biology·Marilyne Stuart, Chantal Houée-Levin

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