PMID: 6987490Jan 1, 1980Paper

gamma-Ray induced mutational spectrum in the lacI gene of Escherichia coli: comparison of induced and spontaneous spectra at the molecular level

Mutation Research
B W GlickmanC S Aaron

Abstract

The spectrum of mutations induced by ionizing radiation (gamma-rays) was determined in the lacI gene of E. coli. Base substitution was the principal type of mutational event following ionizing radiation. Both transitions and transversions were produced, and no strong specificity for a particular base pair was observed. The spectra of spontaneous and of ionizing-radiation-induced base-pair changes differed significantly at several locations within the lacI gene. The location of 3 of these differences corresponded to sites of spontaneous deamination "hot spots" from which we conclude that gamma-rays do not cause extensive deamination. The specific locus rate was calculated as 4.5 X 10(-10) mutations per rad per gene copy per cell, and the nucleotide substitution rate was 2.2 X 10(-12) per rad. The frameshift mutation, trpE997, was not reverted by gamma-rays.

References

Feb 14, 1975·Science
Aug 24, 1978·Nature·P J Farabaugh
Nov 1, 1978·Mutation Research·B A Bridges, R P Mottershead
Jan 1, 1979·Cold Spring Harbor Symposia on Quantitative Biology·M RadmanS Spadari
Dec 15, 1977·Journal of Molecular Biology·C Coulondre, J H Miller
Apr 1, 1976·Genetics·M A ConklingJ W Drake
May 1, 1974·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·J F Bleichrodt, W S Verheij
Feb 1, 1969·Genetics·D O Schwartz, J R Beckwith
Jul 18, 1964·Nature·R J MUNSON, B A BRIDGES

❮ Previous
Next ❯

Citations

Jan 1, 1983·Molecular & General Genetics : MGG·A Kolman, M Näslund
Nov 1, 1986·Somatic Cell and Molecular Genetics·G UrlaubJ Hamlin
Dec 1, 1986·Mutation Research·G DasF Sherman
Jun 1, 1987·Mutation Research·L Shirnamé-MoréK Frenkel
May 1, 1993·Mutation Research·J RetèlM V Lafleur
Dec 1, 1989·Mutation Research·B TokarovaE A Krasavin
Jan 22, 2002·Advances in Space Research : the Official Journal of the Committee on Space Research (COSPAR)·A TakahashiT Ohnishi
Jan 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·A J GrosovskyB W Glickman
Oct 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·A K BasuJ M Essigmann
Jan 3, 1995·Proceedings of the National Academy of Sciences of the United States of America·Y KubotaA Shima
Feb 13, 2010·International Journal of Radiation Biology·Ryouhei YoshiharaIssay Narumi
Jul 16, 1985·Biochemistry·L H Breimer, T Lindahl
Jan 1, 1997·Environmental and Molecular Mutagenesis·A D da Cruz, B W Glickman
Jun 1, 1992·International Journal of Radiation Biology·S KozubekG Horneck
Feb 1, 1983·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·R D WoodA Poley
Jan 1, 1994·Mutation Research·K TakimotoK Ishizaki

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.