PMID: 8951684Jan 1, 1996Paper

Gamma scintigraphic comparison of eyedrops containing pilocarpine in healthy volunteers

Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics
G MeseguerR Gurny

Abstract

The aim of the present study was to compare, in healthy human volunteers (male and female), the corneal contact time of various formulations, each containing one viscosity enhancer from the following list: a phase-transition system (gellan gum, Gelrite), a heteropolysaccharide (xanthan gum) and currently used polymers hydroxyethylcellulose, hydroxypropylmethylcellulose, or poly(vinyl alcohol). These different solutions were compared to a reference solution containing no viscosity enhancers. The corneal contact time of the formulations was evaluated over more than 20 minutes by gamma scintigraphy using Technetium-99m (Tc-99m DTPA) as a radioactive label. An eyedrop containing pilocarpine salts (25 microliters) was instilled in one eye only. Each volunteer received 4 formulations, the interval between the instillations being one week. The protocol has been approved by the relevant institutional human experimentation committee. One minute after instillation, only 23% of the reference solution remained on the ocular surface, whereas the novel formulations maintained, respectively, 77% (xanthan gum) or 82% (Gelrite) of the tracer on the ocular surface. Twenty-one min after instillation, 12% (reference solution), 25% (xanthan gum sol...Continue Reading

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Citations

Nov 4, 2010·Advances in Therapy·Charles L BalzliRichard J O'Callaghan
Feb 11, 1999·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·L Van Santvliet, A Ludwig
Dec 12, 2012·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Kishore CholkarAshim K Mitra
Dec 18, 2013·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·K BellF H Grus
Jun 19, 2012·Expert Opinion on Drug Delivery·Priyanka PahujaPravin Pawar
Jul 9, 2002·Drug Development and Industrial Pharmacy·Indu Pal Kaur, Meenakshi Kanwar
Mar 25, 2014·International Journal of Pharmaceutics·Tomasz OsmałekSylwia Tasarek
Oct 28, 2005·Current Eye Research·Heng Zhu, Anuj Chauhan
Jan 2, 2001·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·S BurgalassiM F Saettone
May 19, 2019·Pharmaceutics·Ana Castro-BaladoAnxo Fernández-Ferreiro
Jan 1, 2013·World Journal of Pharmacology·Ashaben PatelAshim K Mitra
Nov 16, 2002·Current Eye Research·William C StewartChaney E Hott
Sep 1, 2015·Advances in Colloid and Interface Science·Samuel GauseAnuj Chauhan

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